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Year 1573 (MDLXXIII) was a common year starting on Thursday (link will display the full calendar) of the Julian calendar.
- July 6 – Córdoba, in the Viceroyalty of Peru, is founded by Jerónimo Luis de Cabrera.
- July 12 – Siege of Haarlem: Spanish forces under the Duke of Alva capture Haarlem, after a seven-month siege.
- July – The Edict of Boulogne is signed by Charles IX of France, granting limited rights to Huguenots, and ending the Fourth War of Religion in France.
- August – Alva begins to besiege Alkmaar in North Holland.
- August 27 – Oda Nobunaga drives the 15th Ashikaga sh?gun Ashikaga Yoshiaki out of Kyoto, effectively destroying the Ashikaga shogunate, and historically ending the Muromachi and Sengoku periods. The Azuchi-Momoyama period of Japan begins.
- September 8–16 – Siege of Hikida Castle, Siege of Ichij?dani Castle in Japan: The Asakura clan is eliminated by Oda Nobunaga.
- September 22–26 – Siege of Odani Castle in Japan: The Azai clan is eliminated by Oda Nobunaga.
- October 8 – The Spanish abandon the siege of the city of Alkmaar.
- November 15 – Santa Fe, Argentina, is founded by Juan de Garay.
- November – Alva resigns as Spanish Governor-General and Commander-in-Chief in the Netherlands, and is succeeded by Luis de Requesens, who attempts to pursue a more conciliatory policy.
- Sarsa Dengel, emperor of Ethiopia, defeats the Oromo in a battle near Lake Zway.
- The first Spanish galleon, laden with silver for the porcelain and silk trade with the Ming Dynasty of China, lands at Manila in the Philippines. This occasion marks the beginning of the Spanish silver trade to China, that will trump that of the Portuguese, the latter of whom acted as an intermediary between the silver mines of Japan, and the luxury items in China to be purchased with that silver. Most of the silver entering China comes from what is now Mexico, Bolivia, and Peru in the New World.
- The Luzhou Laojiao liquor is made.
- The Portuguese are expelled from the Maldives.
- Queen Elizabeth's Grammar School for Boys, Barnet, England, is formed.
- January 1 – Philippus Rovenius, Dutch priest (d. 1651)
- January 10 – Simon Marius, German astronomer (d. 1624)
- January 18 – Ambrosius Bosschaert, still life painter of the Dutch Golden Age (d. 1621)
- January 20 – Alexander, Duke of Schleswig-Holstein-Sonderburg (d. 1627)
- January 22 – Ludwig Camerarius, German politician (d. 1651)
- January 30 – Georg Friedrich, Margrave of Baden-Durlach (1604-1622) (d. 1638)
- February 28 – Elias Holl, German architect (d. 1646)
- March 12 – Agnes Hedwig of Anhalt, Abbess of Gernrode, Electress of Saxony, Duchess of Schleswig-Holstein-Sønderborg-Plön (d. 1616)
- March 24 – Giovanni Doria, Spanish noble (d. 1642)
- April 6 – Margaret of Brunswick-Lüneburg, German noble (d. 1643)
- April 12 – Jacques Bonfrère, Flemish Jesuit priest, biblical scholar (d. 1642)
- April 13 – Christina of Holstein-Gottorp, Queen of Sweden (d. 1625)
- April 17 – Maximilian I, Elector of Bavaria (d. 1651)
- April 28 – Charles de Valois, Duke of Angoulême, natural son of Charles IX of France (d. 1650)
- May 12 – Henri, Duke of Montpensier, French noble (d. 1608)
- June 12 – Robert Radclyffe, 5th Earl of Sussex, British Earl (d. 1629)
- June 16 – Andries de Witt, Grand Pensionary of Holland (d. 1637)
- June 28 – Henry Danvers, 1st Earl of Danby, English noble (d. 1643)
- June – Juan Pau Pujol, Catalan composer and organist (d. 1626)
- July 12 – Pietro Carrera, Italian priest, painter and saint (d. 1647)
- July 14 – Bonaventure Hepburn, Scottish philologist and Minim friar (d. 1620)
- July 15 – Inigo Jones, English architect (d. 1652)
- July 18 – Odoardo Fialetti, Italian painter (d. 1638)
- July 25 – Christoph Scheiner, German astronomer and Jesuit (d. 1650)
- July 29 – Philip II, Duke of Pomerania-Stettin (d. 1618)
- August 16 – Anne of Austria, Queen of Poland (d. 1598)
- August 25 – Elizabeth of Denmark, Duchess of Brunswick-Wolfenbüttel, German regent (d. 1626)
- September 8 – Georg Friedrich von Greiffenklau, Archbishop of Mainz (d. 1629)
- September 28 – Théodore de Mayerne, Swiss physician (d. 1654)
- September 29 – Robert Payne, English politician (d. 1631)
- October 6 – Henry Wriothesley, 3rd Earl of Southampton (d. 1624)
- October 7 – William Laud, Archbishop of Canterbury (d. 1645)
- October 11 – Jacobus Boonen, Dutch Catholic archbishop (d. 1655)
- November 3 – Catherine of Lorraine, Abbess of Remiremont (d. 1648)
- November 29 – Johannes Canuti Lenaeus, archbishop of Uppsala (d. 1669)
- November 30 – Aubert Miraeus, Belgian historian (d. 1640)
- December 6 – Odoardo Farnese, Italian Catholic cardinal (d. 1626)
- December 21 – Mathurin Régnier, French satirist (d. 1613)
- December 22 – Ernest Casimir I, Count of Nassau-Dietz (1606-1632) and Stadtholder of Groningen, Friesland and Drenthe (1625-1632) (d. 1632)
- December 23 – Giovanni Battista Crespi, Italian painter (d. 1632)
- date unknown
- January 1
- January 12 – William Howard, 1st Baron Howard of Effingham, English Lord High Admiral (b. 1510)
- February 7 – Hedwig Jagiellon, Electress of Brandenburg (b. 1513)
- March 2 – Johann Wilhelm, Duke of Saxe-Weimar (b. 1530)
- March 3 – Claude, Duke of Aumale, third son of Claude, Duke of Guise (b. 1526)
- March 13 – Michel de l'Hôpital, French statesman (b. 1505)
- April 2 – Otto Truchsess von Waldburg, German Catholic cardinal (b. 1514)
- April 7 – Andreas Masius, Flemish Catholic priest (b. 1514)
- April 29 – Guillaume Le Testu, French privateer (b. 1509)
- May 13 – Takeda Shingen, Japanese warlord (b. 1521)
- May 14 (bur.) – Richard Grafton, English merchant and printer (b. c.1506/7)
- June 15 – Antun Vran?i?, Croatian archbishop (b. 1504)
- July – Étienne Jodelle, French dramatist and poet (b. 1532)
- July 7 – Giacomo Barozzi da Vignola, Italian architect (b. 1507)
- July 16 – Wigbolt Ripperda, mayor of Haarlem, Netherlands
- July 29
- August 14 – Sait? Tatsuoki, Japanese warlord (b. 1548)
- September 7 – Joanna of Austria, Princess of Portugal (b. 1535)
- September 16 – Asakura Yoshikage, Japanese warlord (b. 1533)
- September 23 – Azai Hisamasa, Japanese warlord (b. 1526)
- September 26 – Azai Nagamasa, Japanese warlord (b. 1545)
- October 27 – Laurentius Petri, first Lutheran Archbishop of Sweden (b. 1499)
- November 9 – Shimazu Katsuhisa, Japanese nobleman (b. 1503)
- November 17 – Juan Ginés de Sepúlveda, Spanish philosopher and theologian (b. 1494)
- December 30 – Giovanni Battista Giraldi, Italian novelist and poet (b. 1504)
- date unknown