Baeyer-Emmerling Indole Synthesis
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Baeyer%E2%80%93Emmerling Indole Synthesis
Baeyer-Emmerling indole synthesis
Named after Adolf von Baeyer
Adolph Emmerling
Reaction type Ring forming reaction

The Baeyer-Emmerling indole synthesis is a method for synthesizing indole from a (substituted) ortho-nitrocinnamic acid and iron powder in strongly basic solution.[1][2] This reaction was discovered by Adolf von Baeyer and Adolph Emmerling in 1869.[3][4]

Baeyer-Emmerling indole synthesis

Reaction mechanism

The reaction of iron powder with o-nitrocinnamic acid reduces the nitro group to a nitroso. The nitrogen then condenses with a carbon on the alkene chain with loss of a molecule of water to form a ring. Decarboxylation gives indole.

Baeyer-Emmerling indole reaction mechanism

See also

References

  1. ^ Bayer, A.; Emmerling, A. (1869). "Synthese des indoles" [Synthesis of indoles]. Berichte der deutschen chemischen Gesellschaft. 2 (1): 679-682. doi:10.1002/cber.186900201268.
  2. ^ Baeyer 5. Pmf.ukim.edu.mk (1997-07-30). Retrieved on 2014-01-10.
  3. ^ Chamberlain, Joseph Scudder (1921). A Textbook of Organic Chemistry. Blakiston. p. 874.
  4. ^ Lockyer, Sir Norman (1881). "Indigo and its Artificial Production". Nature. 24 (610): 227-231. Bibcode:1881Natur..24..227H. doi:10.1038/024227c0.

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