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On 30 April 1732, he married Anne Marie de Champagne de Villaines de la Suze.
From 13 October 1761 to 8 April 1766, he served as Secretary of State (minister) for Foreign Affairs, replacing in this office his cousin Étienne de Choiseul (who became in 1763 Secretary of State for War and for Navy). He was lieutenant general of the Armies. In 1763, he was made duke of Praslin and peer of France. He negotiated the peace that ended the Seven Years' War and was Louis XV's plenipotentiary for the conclusion of the Treaty of Paris, which he signed, on 10 February 1763.
From 10 April 1766 to 24 December 1770, he served as Secretary of State for the Navy (his cousin Étienne then taking back the department of Foreign Affairs in addition to that of War). During his term in office, he restored the strength of the Navy, which had been severely damaged during the Seven Years' War. After the death, in 1764, of Madame de Pompadour, who had been their protector, the position of César Gabriel and his cousin Étienne was undermined. He fell from grace in Louis XV's court and withdrew from public affairs in 1770, at the height of the Falkland Crisis involving Britain and Spain. He was replaced at the Navy by abbé Terray.
His titles included marquis of Choiseul, count of Chevigny and of La Rivière, viscount of Melun and of Vaux, baron of La Flèche and of Giry, lord of Chassy. He was made a knight of the Order of the Holy Spirit on 1 January 1762. He was made an honorary member of the Academy of Sciences on 15 December 1769.