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Deuterated chloroform
Stereo, skeletal formula of deuterated chloroform
Spacefill model of deuterated chloroform
IUPAC name
Other names
3D model (JSmol)
ECHA InfoCard 100.011.585 Edit this at Wikidata
EC Number
  • 212-742-4
UN number 1888
  • InChI=1S/CHCl3/c2-1(3)4/h1H/i1D checkY
  • InChI=1/CHCl3/c2-1(3)4/h1H/i1D
  • [2H]C(Cl)(Cl)Cl
Molar mass 120.384 g mol-1
Density 1.500 g cm-3
Melting point -64 °C (-83 °F; 209 K)
Boiling point 61 °C (142 °F; 334 K)
GHS labelling:
GHS05: CorrosiveGHS07: Exclamation markGHS08: Health hazard
H302, H315, H319, H331, H336, H351, H361, H372, H373
P201, P202, P260, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P340, P305+P351+P338, P308+P313, P311, P312, P314, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501
NFPA 704 (fire diamond)
Related compounds
Related compounds

Deuterated dichloromethane

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Deuterated chloroform (CDCl3), also known as chloroform-d, is an isotopically enriched form of chloroform (CHCl3) in which most of its hydrogen atoms consist of the heavier nuclide deuterium (heavy hydrogen) (D = 2H) rather than the natural isotopic mixture in which protium (1H) is predominant.[2] Deuterated chloroform is by far the most common solvent used in NMR spectroscopy.[3] While dichloromethane and chloroform (trichloromethane) are both commonly used solvents that dissolve a wide range of other organic compounds, deuterated chloroform is more easily produced and much less expensive than deuterated dichloromethane.[4] In addition, it is chemically unreactive and unlikely to exchange its deuterium with its solute, and its low boiling point allows for easy sample recovery.[]

The properties of CDCl3 are virtually identical to those of regular chloroform, although biologically, it is slightly less toxic to the liver than CHCl3, due to its C-D bond, which is stronger than a C-H bond, making it somewhat less prone to form the destructive trichloromethyl radical (oCCl3).[5]

NMR solvent

In proton NMR spectroscopy, deuterated solvent (enriched to >99% deuterium) must be used to avoid recording a large interfering signal or signals from the proton(s) (i.e., hydrogen-1) present in the solvent itself. If nondeuterated chloroform (containing a full equivalent of protium) were used as solvent, the solvent signal would almost certainly overwhelm and obscure any nearby analyte signals. In addition, modern instruments usually require the presence of deuterated solvent, as the field frequency is locked using the deuterium signal of the solvent to prevent frequency drift. Commercial chloroform-d does, however, still contain a small amount (0.2% or less) of non-deuterated chloroform; this results in a small singlet at 7.26 ppm, known as the residual solvent peak, which is frequently used as an internal chemical shift reference.

In carbon-13 NMR spectroscopy, the sole carbon in deuterated chloroform shows a triplet at a chemical shift of 77.16 ppm with the three peaks being about equal size, resulting from splitting by spin coupling to the attached spin-1 deuterium atom (CHCl3 has a chemical shift of 77.36 ppm).[4]

It reacts photochemically with oxygen to form phosgene and hydrogen chloride. Therefore, more expensive alternatives like dichloromethane-d2 or benzene-d6 must be used if the analyte is expected to be highly acid-sensitive. To slow this process and reduce the acidity of the solvent, chloroform-d is stored in brown-tinted bottles, often over copper chips or silver foil as stabilizer. Instead of metals, a small amount of a neutralizing base like potassium carbonate may be added.


Like nondeuterated chloroform, chloroform-d is hepatotoxic and likely to be carcinogenic. In addition, exposure to light and oxygen results in the formation of highly toxic phosgene.


  1. ^ "Chloroform-d".
  2. ^ Since non-enriched hydrogen is mostly protium (99.85%), with only a trace of deuterium (0.15%), this enrichment in deuterium is colloquially, though somewhat inaccurately, described as "replacement" of hydrogen ("H") with deuterium ("D").
  3. ^ Fulmer, Gregory R.; Miller, Alexander J. M.; Sherden, Nathaniel H.; Gottlieb, Hugo E.; Nudelman, Abraham; Stoltz, Brian M.; Bercaw, John E.; Goldberg, Karen I. (2010). "NMR Chemical Shifts of Trace Impurities: Common Laboratory Solvents, Organics, and Gases in Deuterated Solvents Relevant to the Organometallic Chemist" (PDF). Organometallics. 29 (9): 2176-2179. doi:10.1021/om100106e.
  4. ^ a b The Theory of NMR - Solvents for NMR spectroscopy
  5. ^ Goldstein, Robin S. (2013). Toxic interactions. Hewitt, William R., Hook, Jerry B. Burlington: Elsevier Science. ISBN 978-1-4832-6970-2. OCLC 896796140.

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