Phillips started his radio career in 1949 on WHBQ/560 in Memphis with a special studio at the Gayoso Hotel. In 1953 WHBQ moved to the mezzanine floor of the Chisca Hotel. Dewey Phillips was the city's leading radio personality for nine years and was the first to simulcast his "Red, Hot & Blue" show on radio and television. During the 1950s he had 100,000 listeners to his 9pm-midnight slot and he received 3,000 letters a week.
Phillips' on-air persona was a speed-crazed hillbilly, with a frantic delivery and entertaining sense of humor. However, he also had a keen ear for music the listening public would enjoy, and he aired both black and white music, which was abundant in post-World War II Memphis, a booming river city which attracted large numbers of rural blacks and whites (along with their musical traditions). Dr.W. Herbert Brewster, pastor of East Trigg Baptist Church was a frequent guest on Dewey's program. He played a great deal of rhythm and blues, country music, boogie-woogie, and jazz as well as Sun Records artists.
On 10th July 1954, he was the first DJ to broadcast the young Elvis Presley's debut record, "That's All Right/Blue Moon Of Kentucky" (Sun 209), and got Presley to reveal his race in an interview by asking which high school the 19-year-old singer attended (knowing that, because of segregation, his audience would readily know what race attended which schools).
Phillips briefly hosted an afternoon program on WHBQ-TV/13 in the mid-1950s. It mostly consisted of Phillips playing records while he and others clowned around in front of the camera.
Though Phillips was not involved in the payola scandals of the time (as was Freed), he was fired in late 1958 when the station adopted a Top 40 format, phasing out his freeform style. He spent the last decade of his life working at smaller radio stations, seldom lasting long. The popular musical Memphis is said to be based loosely on Dewey Phillips' life and career, although elements crucial in the career of Phillips' contemporary Alan Freed appear to be intermixed as well.
A heavy drinker and longtime drug user, mainly painkillers and amphetamines (which contributed to his manic on-air behavior), Phillips died of heart failure at age 42. He is buried in Hardin County, Tennessee at Crump Cemetery.