Dihedral Angle
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Dihedral Angle
Angle between two planes (?, ?, green) in a third plane (pink) which cuts the line of intersection at right angles

A dihedral angle is the angle between two intersecting planes. In chemistry, it is the angle between planes through two sets of three atoms, having two atoms in common. In solid geometry, it is defined as the union of a line and two half-planes that have this line as a common edge. In higher dimensions, a dihedral angle represents the angle between two hyperplanes.[1] The planes of a flying machine are said to be at positive dihedral angle when both starboard and port main planes are upwardly inclined to the lateral axis. When downwardly inclined they are said to be at a negative dihedral angle.

Mathematical background

When the two intersecting planes are described in terms of Cartesian coordinates by the two equations

the dihedral angle, between them is given by:

and satisfies

Alternatively, if nA and nB are normal vector to the planes, one has

where nA · nB is the dot product of the vectors and || || is the product of their lengths.[2]

The absolute value is required in above formulas, as the planes are not changed when changing all coefficient signs in one equation, or replacing one normal vector by its opposite.

However the absolute values can be and should be avoided when considering the dihedral angle of two half planes whose boundaries are the same line. In this case, the half planes can be described by a point P of their intersection, and three vectors b0, b1 and b2 such that P + b0, P + b1 and P + b2 belong respectively to the intersection line, the first half plane, and the second half plane. The dihedral angle of these two half planes is defined by

,

and satisfies

In polymer physics

In some scientific areas such as polymer physics, one may consider a chain of points and links between consecutive points. If the points are sequentially numbered and located at positions r1, r2, r3, etc. bond vectors are defined by u1=r2-r1, u2=r3-r2, and ui=ri+1-ri, more generally.[3] This is the case for kinematic chains or amino acids in a protein structure. In these cases, one is often interested in the planes defined by three consecutive points, and the dihedral angle between two consecutive such planes. If an orientation has been chosen for the whole chain, each pair of consecutive points defines a vector, and the sum of all these vectors ui is the vector pointining from the beginning to the end of the chain. If u1, u2 and u3 are three consecutive such vectors, one has a situation that is similar to the preceding case, except that the intersection of the planes is oriented. This allows defining a dihedral angle that belongs to the interval (-?, ?]. This dihedral angle is defined by[4]

or, using the function atan2,

This dihedral angle does not depend on the orientation of the chain (order in which the point are considered). In fact, changing this ordering consists of replacing each vector by its opposite vector, and exchanging the indices 1 and 3. Both operations do not change the cosine, and change the sign of the sine. Thus, together, they do not change the angle.

A simpler formula for the same dihedral angle is the following (the proof is given below)

or equivalently,

This can be deduced from previous formulas by using the vector quadruple product formula, and the fact that a scalar triple product is zero if it contains twice the same vector:

Special cases are , and , which are called the trans, gauche+, and gauche- conformations.

In stereochemistry

Synantipericlinal.svg Newman projection butane -sc.svg Sawhorse projection butane -sc.png
Configuration names
according to dihedral angle
syn n-Butane
Newman projection
syn n-Butane
sawhorse projection
Free energy diagram of n-butane as a function of dihedral angle.

In stereochemistry, a torsion angle is defined as a particular example of a dihedral angle, describing the geometric relation of two parts of a molecule joined by a chemical bond.[5][6] Every set of three not-colinear atoms of a molecule defines a plane. When two such planes intersect (i.e., a set of four consecutively-bonded atoms), the angle between them is a dihedral angle. Dihedral angles are used to specify the molecular conformation.[7]Stereochemical arrangements corresponding to angles between 0° and ±90° are called syn (s), those corresponding to angles between ±90° and 180° anti (a). Similarly, arrangements corresponding to angles between 30° and 150° or between -30° and -150° are called clinal (c) and those between 0° and ±30° or ±150° and 180° are called periplanar (p).

The two types of terms can be combined so as to define four ranges of angle; 0° to ±30° synperiplanar (sp); 30° to 90° and -30° to -90° synclinal (sc); 90° to 150° and -90° to -150° anticlinal (ac); ±150° to 180° antiperiplanar (ap). The synperiplanar conformation is also known as the syn- or cis-conformation; antiperiplanar as anti or trans; and synclinal as gauche or skew.

For example, with n-butane two planes can be specified in terms of the two central carbon atoms and either of the methyl carbon atoms. The syn-conformation shown above, with a dihedral angle of 60° is less stable than the anti-conformation with a dihedral angle of 180°.

For macromolecular usage the symbols T, C, G+, G-, A+ and A- are recommended (ap, sp, +sc, -sc, +ac and -ac respectively).

Proteins

Depiction of a protein, showing backbone dihedral angles

A Ramachandran plot (also known as a Ramachandran diagram or a [?,?] plot), originally developed in 1963 by G. N. Ramachandran, C. Ramakrishnan, and V. Sasisekharan,[8] is a way to visualize energetically allowed regions for backbone dihedral angles ? against ? of amino acid residues in protein structure. The figure at right illustrates the definition of the ? and ? backbone dihedral angles[9] (called ? and by Ramachandran).

In a protein chain three dihedral angles are defined as ? (phi), ? (psi) and ? (omega), as shown in the diagram. The planarity of the peptide bond usually restricts ? to be 180° (the typical trans case) or 0° (the rare cis case). The distance between the C? atoms in the trans and cis isomers is approximately 3.8 and 2.9 Å, respectively. The vast majority of the peptide bonds in proteins are trans, though the peptide bond to the nitrogen of proline has an increased prevalence of cis compared to other amino-acid pairs.[10]

The side chain dihedral angles are designated with ?n (chi-n).[11] They tend to cluster near 180°, 60°, and -60°, which are called the trans, gauche+, and gauche- conformations. The stability of certain sidechain dihedral angles is affected by the values ? and ?.[12] For instance, there are direct steric interactions between the C? of the side chain in the gauche+ rotamer and the backbone nitrogen of the next residue when ? is near -60°.[13]

Converting from dihedral angles to Cartesian coordinates in chains

It is common to represent polymers backbones, notably proteins, in internal coordinates; that is, a list of consecutive dihedral angles and bond lengths. However, some types of computational chemistry instead use cartesian coordinates. In computational structure optimization, some programs need to flip back and forth between these representations during their iterations. This task can dominate the calculation time. For processes with many iterations or with long chains, it can also introduce cumulative numerical inaccuracy. While all conversion algorithms produce mathematically identical results, they differ in speed and numerical accuracy.[14][non-primary source needed]

Geometry

Every polyhedron has a dihedral angle at every edge describing the relationship of the two faces that share that edge. This dihedral angle, also called the face angle, is measured as the internal angle with respect to the polyhedron. An angle of 0° means the face normal vectors are antiparallel and the faces overlap each other, which implies that it is part of a degenerate polyhedron. An angle of 180° means the faces are parallel, as in a tiling. An angle greater than 180° exists on concave portions of a polyhedron.

Every dihedral angle in an edge-transitive polyhedron has the same value. This includes the 5 Platonic solids, the 13 Catalan solids, the 4 Kepler-Poinsot polyhedra, the two quasiregular solids, and two quasiregular dual solids.

Given 3 faces of a polyhedron which meet at a common vertex P and have edges AP, BP and CP, the cosine of the dihedral angle between the faces containing APC and BPC is:[15]

See also

References

  1. ^ Olshevsky, George. "Dihedral angle". Glossary for Hyperspace. Archived from the original on 4 February 2007. Cite has empty unknown parameter: |1= (help)
  2. ^ "Angle Between Two Planes". TutorVista.com. Retrieved .
  3. ^ Kröger, Martin (2005). Models for polymeric and anisotropic liquids. Springer. ISBN 3540262105.
  4. ^ Blondel, Arnaud; Karplus, Martin (7 Dec 1998). "New formulation for derivatives of torsion angles and improper torsion angles in molecular mechanics: Elimination of singularities". Journal of Computational Chemistry. 17 (9): 1132-1141. doi:10.1002/(SICI)1096-987X(19960715)17:9<1132::AID-JCC5>3.0.CO;2-T.
  5. ^ IUPAC, Compendium of Chemical Terminology, 2nd ed. (the "Gold Book") (1997). Online corrected version:  (2006–) "Torsion angle". doi:10.1351/goldbook.T06406
  6. ^ IUPAC, Compendium of Chemical Terminology, 2nd ed. (the "Gold Book") (1997). Online corrected version:  (2006–) "Dihedral angle". doi:10.1351/goldbook.D01730
  7. ^ Anslyn, Eric; Dennis Dougherty (2006). Modern Physical Organic Chemistry. University Science. p. 95. ISBN 978-1891389313.
  8. ^ Ramachandran, G. N.; Ramakrishnan, C.; Sasisekharan, V. (1963). "Stereochemistry of polypeptide chain configurations". Journal of Molecular Biology. 7: 95-9. doi:10.1016/S0022-2836(63)80023-6. PMID 13990617.
  9. ^ Richardson, J. S. (1981). Anatomy and Taxonomy of Protein Structures. Advances in Protein Chemistry. 34. pp. 167-339. doi:10.1016/S0065-3233(08)60520-3. ISBN 9780120342341. PMID 7020376.
  10. ^ Singh J, Hanson J, Heffernan R, Paliwal K, Yang Y, Zhou Y (August 2018). "Detecting Proline and Non-Proline Cis Isomers in Protein Structures from Sequences Using Deep Residual Ensemble Learning". Journal of Chemical Information and Modeling. 58 (9): 2033-2042. doi:10.1021/acs.jcim.8b00442. PMID 30118602.
  11. ^ http://www.cryst.bbk.ac.uk/PPS95/course/3_geometry/conform.html
  12. ^ Dunbrack, RL Jr.; Karplus, M (20 March 1993). "Backbone-dependent rotamer library for proteins. Application to side-chain prediction". Journal of Molecular Biology. 230 (2): 543-74. doi:10.1006/jmbi.1993.1170. PMID 8464064.
  13. ^ Dunbrack, RL Jr; Karplus, M (May 1994). "Conformational analysis of the backbone-dependent rotamer preferences of protein sidechains". Nature Structural Biology. 1 (5): 334-40. doi:10.1038/nsb0594-334. PMID 7664040.
  14. ^ Parsons, J.; Holmes, J. B.; Rojas, J. M.; Tsai, J.; Strauss, C. E. (2005), "Practical conversion from torsion space to cartesian space for in silico protein synthesis", Journal of Computational Chemistry, 26 (10): 1063-1068, doi:10.1002/jcc.20237, PMID 15898109
  15. ^ "dihedral angle calculator polyhedron". www.had2know.com. Archived from the original on 25 November 2015. Retrieved 2015.

External links


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