Little is known of his birth, though he is thought to have been born in Venice, hence his last name. He then moved to Florence in 1422-23 as a boy, to become a pupil of Gentile da Fabriano. He is said to have worked with Pisanello in Rome around 1423-1430. His work was influenced by the style of Benozzo Gozzoli.
In a letter from him to Piero di Cosimo de' Medici, dated from Perugia in 1438, where he likewise resided for many years, he mentions his long connection with the fortunes of the Medici family, and begs to be allowed to paint an altarpiece for the head of that house. He was a contemporary with Fra Angelico and Fra Filippo Lippi, since those two artists and himself are known to have valued the frescoes of Buonfigli at Perugia. Between 1439 and 1441 he painted a masterpiece of the Adoration of the Magi.
Another masterpiece is considered to be the Santa Lucia de' Magnoli Altarpiece (c. 1445-1447), originally in Santa Lucia dei Magnoli, Florence and now in the Uffizi. Painted in tempera on panel, the altarpiece displays such an unusual palette for this period that Vasari wrote that it had been painted in oil. Domenico is also known for a round panel of the Adoration of the Magi (1439-1441) which was probably commissioned for the palace of the wealthy Medici family and now in Berlin. He influenced Andrea Mantegna.
He worked at the decorations of the Portinari chapel in the hospital of Santa Maria Nuova in Florence from 1439-1445, and had as his assistants Piero della Francesca and Bicci di Lorenzo. It is certain that whilst employed there he used linseed oil as his medium, since the hospital books of that date make many allusions to this item in his expenses. His latter days were spent in Florence, where he died on May 15, 1461.
The predella included panels with scenes of the saints of the main composition, and a central, double-size Annunciation: the Stygmata of St. Francis and John Baptist in the Desert are currently in the National Gallery of Art in Washington, the Annunciation and The Miracle of St. Zenobius are in the Fitzwilliam Museum of Cambridge, and the Martyrdom of St. Lucy is in the Berlin State Museums.
Media related to Domenico Veneziano at Wikimedia Commons