It is not known when Liang Nüying was born, but what is known is that in her young age she was accustomed to an honored position as the daughter of the Grand Marshal Liang Shang () and the sister to Empress Liang Na, Emperor Shun's wife, and later regent to his son Emperor Chong, and two successors from collateral lines, Emperors Zhi and Huan. Indeed, it was because she was betrothed to Emperor Huan (who was then the Marquess of Liwu) that her brother, the powerful Liang Ji, insisted on making him emperor in 146 after poisoning Emperor Zhi. After Emperor Huan became emperor, he married her in 147 and created her empress.
As an empress, Empress Liang was somewhat in the shadow of her sister, the empress dowager, and brother, and not much is known about her. Traditional history indicates that because of her honored position as the empress dowager's sister, initially, Emperor Huan did not dare to have any other favorite consorts. She was described as so luxurious in her living that her expenses far exceeded the empresses of the past. After her sister died in 150, she began to lose Emperor Huan's favor, but she continued to be greatly jealous. As she was sonless, she did not want any imperial consorts to have sons--so she would have them killed if they became pregnant. With Liang Ji effectively in control of government, Emperor Huan did not dare to respond, but he would rarely have sexual relations with her. Empress Liang died in anger on August 9, 159 and was buried with the honors of an empress.
Later that year, Emperor Huan, in conjunction with eunuchs, overthrew Liang Ji in a coup d'etat. The Liang clan was slaughtered. On September 29, Empress Liang's tomb was retitled a tomb of an "Honored Lady", effectively meaning that she was posthumously demoted.
On the 28th day of the August of that same year, she was buried in Yiling.
In the autumn, in the seventh month on the day bingwu [9 Aug], the Empress Liang died.
On the day renwu [14 Sep] the Honoured Lady Liang [Meng] was established as Empress. The Yiling Tomb [of the late Empress Liang Nüying] was demoted to be the tomb of an Honoured Lady.
On the day yichou [28 Aug] the Gentle and Generous Empress was buried at Yiling