Frans Pietersz de Grebber (1573 – c. 1649) was a Dutch Golden Age painter.
De Grebber was born and died in Haarlem. According to van Mander he was a good painter of landscapes and portraits, who designed tapestries and had been a pupil of Jacob Savery. According to Houbraken he had two children who were notable painters; Pieter de Grebber, who outshone his father, and Maria de Grebber, who was good with buildings and perspective.
According to the RKD he became a member of the Haarlem Guild of St. Luke around 1600 and remained an important citizen in Haarlem until his death. Besides his children, he taught the painters Vincent Casteleyn, Peter Lely, Judith Leyster, and Pieter Saenredam.