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The Gillespie V. Montgomery Lock (formerly named Lock E) is part of the Tennessee-Tombigbee Waterway (popularly known as the Tenn-Tom). It is located in north Itawamba County, Mississippi, close to the Prentiss County line.
It is the northernmost of a series of five locks within the Tenn-Tom referred to as the "Chain of Lakes" or "Canal" section. The lock has a lift of 30 feet and cost US$30 million.