Alexander Hardy, CEO Ed Harrington Sandra J. Horning, M.D. Michael D. Varney, Stephen Williams, Ph.D. Sean Johnston Kimball Hall Nancy Vitale Severin Schwan, Chairman of Genentech Board of Directors, CEO of Roche Group
In 2006 Genentech acquired Tanox in its first acquisition deal. Tanox had started developing Xolair and development was completed in collaboration with Novartis and Genentech; the acquisition allowed Genentech to keep more of the revenue.
in March 2009 Roche acquired Genentech by buying shares it didn't already control for approximately $46.8 billion.
In July 2014, Genentech/Roche acquired Seragon for its pipeline of small-molecule cancer drug candidates for $725 million cash upfront, with an additional $1 billion of payments dependent on successful development of products in Seragon's pipeline.
Genentech was a pioneering research-driven biotechnology company that has continued to conduct R&D internally as well as through collaborations.
Genentech's research collaborations include:
In 2008 Genentech entered into a collaboration with Roche and its subsidiary GlycArt to develop obinutuzumab.
In December 2006, Genentech sold its Porriño, Spain, facility to Lonza and acquired an exclusive right to purchase Lonza's mammalian cell culture manufacturing facility under construction in Singapore. In June 2007, Genentech began the construction and development of an E. coli manufacturing facility, also in Singapore, for the worldwide production of Lucentis (ranibizumab injection) bulk drug substance.
Genentech Inc Political Action Committee
Genentech Inc Political Action Committee is a U.S. Federal Political Action Committee (PAC), created to "aggregate contributions from members or employees and their families to donate to candidates for federal office."
In November 1999, Genentech agreed to pay the University of California, San Francisco $200 million to settle a nine-year-old patent dispute. In 1990, UCSF sued Genentech for $400 million in compensation for alleged theft of technology developed at the university and covered by a 1982 patent. Genentech claimed that they developed Protropin (recombinant somatotropin/human growth hormone), independently of UCSF. A jury ruled that the university's patent was valid in July 1999, but wasn't able to decide whether Protropin was based upon UCSF research or not. Protropin, a drug used to treat dwarfism, was Genentech's first marketed drug and its $2 billion in sales has contributed greatly to its position as an industry leader. The settlement was to be divided as follows: $30 million to the University of California General Fund, $85 million to the three inventors and two collaborating scientists, $50 million towards a new teaching and research campus for UCSF, and $35 million to support university-wide research.
1982: Synthetic "human" insulin approved by the U.S. Food and Drug Administration (FDA), partnered with insulin manufacturer Eli Lilly and Company, who shepherded the product through the FDA approval process. The product (Humulin) was licensed to and manufactured by Lilly, and was the first-ever approved genetically engineered human therapeutic.
1998: Herceptin (trastuzumab): Treatment for metastatic breast cancer patients with tumors that overexpress the HER2 gene. Recently approved for adjuvant therapy for breast cancer. FDA also recently approved Trastuzumab for metastatic gastric cancer with HER2 receptor site positive.
2004: Avastin (bevacizumab): Anti-VEGF monoclonal antibody for the treatment of metastatic cancer of the colon or rectum. In 2006, also approved for locally advanced, recurrent or metastatic non-small cell lung cancer. In 2008, accelerated approval was granted for Avastin in combination with chemotherapy for previously untreated advanced HER2-negative breast cancer. In 2009, Avastin gained its fifth approval for treatment of glioblastoma multiforme, and sixth approval for the treatment of metastatic renal cell carcinoma. It was most publicized for its approval in advanced breast cancer treatment, but the FDA approval for breast cancer treatment was subsequently revoked in November, 2011.
2004: Tarceva (erlotinib): Treatment for patients with locally advanced or metastatic non-small cell lung cancer, and pancreatic cancer.
2006: Lucentis (ranibizumab injection): Treatment of neovascular (wet) age-related macular degeneration (AMD). The FDA approved LUCENTIS after a Priority Review (six-month). Genentech started shipping product on June 30, 2006, the day the product was approved.
2010: Actemra (tocilizumab): The first interleukin-6 (IL-6) receptor-inhibiting monoclonal antibody approved to treat rheumatoid arthritis (RA).
2011: Zelboraf (vemurafenib): For the treatment of a type of skin cancer called melanoma that has spread to other parts of the body or cannot be removed by surgery, and has a certain type of abnormal BRAF gene.
2012: Perjeta (pertuzumab): For use in combination with Herceptin (trastuzumab) and docetaxel chemotherapy for the treatment of patients with previously untreated HER2-positive metastatic breast cancer.
2013: Kadcyla (ado-trastuzumab emtansine): The first Genentech antibody-drug conjugate (ADC) to receive FDA approval. It consists of trastuzumab (Herceptin) linked to a cytotoxic agent mertansine (DM1), used in the treatment of HER2-positive metastatic breast cancer.
2014: Esbriet (pirfenidone): An anti-fibrotic drug for the treatment of idiopathic pulmonary fibrosis (IPF). Developed by Intermune, Inc.
2015: Cotellic (cobimetinib): For use in combination with ZELBORAF (vemurafenib), to treat a type of skin cancer called melanoma that has spread to other parts of the body or cannot be removed by surgery, and that has a certain type of abnormal "BRAF" gene.
2015: Alecensa (alectinib): Treatment for non-small cell lung cancer (NSCLC).
2016: Venclexta (venetoclax): Treatment for patients with chronic lymphocytic leukemia (CLL) who have a chromosomal abnormality called 17p deletion and who have been treated with at least one prior therapy.
2016: Tecentriq (atezolizumab): First-in-class anti-PD-L1 antibody for the treatment of advanced bladder cancer or metastatic non-small cell lung cancer (NSCLC), both after failure of platinum-based chemotherapy. Tecentriq was granted accelerated approval for its advanced bladder cancer indication due to promising phase II results.
2017: Ocrevus (ocrelizumab): The first FDA-approved therapy that treats both relapsing-remitting multiple sclerosis (RRMS) and primary progressive multiple sclerosis (PPMS). The PPMS form of the disease previously had no approved treatments.
2018: Xofluza (Baloxavir marboxil): Antiviral medication for treatment of influenza A and influenza B. Developed by Shionogi.
2019: Polivy (Polatuzumab vedotin-piiq): Treatment of diffuse large B-cell lymphoma when used in combination with bendamustine and rituximab.
Awards and recognitions
Fortune Magazine has listed Genentech on its "100 Best Companies To Work For" for 21 consecutive years, with a number one ranking on its 2006 list. The ranking has varied from number 1 to number 80 throughout the years. The ranking is based on anonymous employee responses to a survey as well as an evaluation of the company's policies and culture.
Genentech was named one of the 100 Best Companies for Working Mothers in 2004, 2006-8 and 2010-11 by Working Mother Magazine.
It was named as one of the 100 best corporate citizens 2006 by the Business Ethics Magazine. The company participates in various policy and civic leadership groups, such as TechNet, and sponsors independent third-party research and publications, such as the journal Nature.
Genentech was named Top Employer by Science Magazine on October 7, 2010, where it has been recognized for nine consecutive years.
In March 2008, Genentech was named Most Admired Pharmaceutical Company by Fortune for the second consecutive year.
In July 2010, Genentech was named on the "Top 100 Best Places to Work in IT" list by ComputerWorld magazine.
^Genentech. "Corporate Overview". Archived from the original on 2012-04-18. Genentech was founded by venture capitalist Robert A. Swanson and biochemist Dr. Herbert W. Boyer. After a meeting in 1976, the two decided to start a biotechnology company, Genentech. Although the two confidently assert that it was the first biotech company, others clearly came before, including Cetus Corporation which was founded in 1971.
^"In January 1976, 28-year-old venture capitalist Robert Swanson entered the picture. A successful cold-call to Boyer's lab led to a couple of beers--and an agreement to start a pharmaceutical company. Investing $500 each, they capitalized a new business, Genentech, to seek practical uses for Boyer and Cohen's engineered proteins. Swanson raised money for staff and labs...""Who made America? Herbert Boyer". PBS.