Indigenous peoples of Panama, or Native Panamanians, are the native peoples of Panama. According to the 2010 census, they make up 12.3% of the overall population of 3.4 million, or just over 418,000 people. The Guaymí and Ngöbe-Buglé comprise half of the indigenous peoples of Panama.
Many of the Indigenous Peoples live on comarca indígenas, which are administrative regions for areas with substantial Indigenous populations. Three comarcas (Comarca Emberá-Wounaan, Guna Yala, Ngöbe-Buglé) exist as equivalent to a province, with two smaller comarcas (Guna de Madugandí and Guna de Wargandí) subordinate to a province and considered equivalent to a corregimiento (municipality).