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He grew up at 11 Crick Road, North Oxford. He learnt to read at the age of three, and at four, after injuring his forehead he asked the doctor, "Is this oxyhaemoglobin or carboxyhaemoglobin?". From age eight he worked with his father in their home laboratory where he experienced his first self-experimentation, the method he would later be famous for. He and his father became their own "human guinea pigs", such as in their investigation on the effects of poison gases. In 1899 his family moved to "Cherwell", a late Victorian house at the outskirts of Oxford with its own private laboratory.
His formal education began in 1897 at Oxford Preparatory School (now Dragon School), where he gained a First Scholarship in 1904 to Eton. In 1905 he joined Eton, where he experienced severe abuse from senior students for allegedly being arrogant. The indifference of authority left him with a lasting hatred for the English education system. However, the ordeal did not stop him from becoming Captain of the school. He studied mathematics and classics at New College at the University of Oxford and obtained first-class honours in mathematical moderations in 1912 and first-class honours in Greats in 1914. He became engrossed in genetics and presented a paper on gene linkage in vertebrates in the summer of 1912. His first technical paper, a 30-page long article on haemoglobin function, was published that same year, as a co-author alongside his father.
His education was interrupted by the First World War during which he fought in the British Army, being commissioned a temporary second lieutenant in the 3rd Battalion of the Black Watch (Royal Highland Regiment) on 15 August 1914. He was promoted to temporary lieutenant on 18 February 1915 and to temporary captain on 18 October. He served in France and Iraq, where he was wounded. He relinquished his commission on 1 April 1920, retaining his rank of captain. For his ferocity and aggressiveness in battles, his commander called him the "bravest and dirtiest officer in my Army."
In 1924, Haldane met Charlotte Franken. So that they could marry, Charlotte divorced her husband, Jack Burghes, causing some controversy. Haldane was almost dismissed from Cambridge for the way he handled his meeting with her. They married in 1926. Following their separation in 1942, the Haldanes divorced in 1945. Later that year he married Helen Spurway.
Haldane, inspired by his father, would expose himself to danger to obtain data. To test the effects of acidification of the blood he drank dilute hydrochloric acid, enclosed himself in an airtight room containing 7% carbon dioxide, and found that it 'gives one a rather violent headache'. One experiment to study elevated levels of oxygen saturation triggered a fit which resulted in him suffering crushed vertebrae. In his decompression chamber experiments, he and his volunteers suffered perforated eardrums. But, as Haldane stated in What is Life, "the drum generally heals up; and if a hole remains in it, although one is somewhat deaf, one can blow tobacco smoke out of the ear in question, which is a social accomplishment."
In 1956, Haldane left University College London, and joined the Indian Statistical Institute (ISI) in Kolkata, India, where he headed the biometry unit. Officially he stated that he left the UK because of the Suez Crisis, writing: "Finally, I am going to India because I consider that recent acts of the British Government have been violations of international law." He believed that the warm climate would do him good, and that India shared his socialist dreams. The university had sacked his wife Helen for excessive drinking and refusing to pay a fine, triggering Haldane's resignation. He declared he would no longer wear socks, "Sixty years in socks is enough." and always dressed in Indian attire.
He was keenly interested in inexpensive research. He wrote to Julian Huxley about his observations on Vanellus malabaricus, the yellow-wattled lapwing. He advocated the use of Vigna sinensis (cowpea) as a model for studying plant genetics. He took an interest in the pollination of Lantana camara. He lamented that Indian universities forced those who took up biology to drop mathematics. Haldane took an interest in the study of floral symmetry. In January 1961 he befriended Gary Botting, 1960 U.S. Science Fair winner in zoology (who had first visited the Haldanes along with Susan Brown, 1960 U.S. National Science Fair winner in botany), inviting him to share the results of his experiments hybridising Antheraea silk moths. J.B.S., his wife Helen Spurway, and Krishna Dronamraju were present at the Oberoi Grand Hotel in Kolkata when Brown reminded the Haldanes that she and Botting had a previously scheduled event that would prevent them from accepting an invitation to a banquet proposed by J.B.S. and Helen in their honour and had regretfully declined the honour. After the two students had left the hotel, Haldane went on his much-publicized hunger strike to protest what he regarded as a "U.S. insult." When the director of the ISI, P. C. Mahalanobis, confronted Haldane about both the hunger strike and the unbudgeted banquet, Haldane resigned from his post (in February 1961), and moved to a newly established biometry unit in Odisha.
Haldane took Indian citizenship; he was interested in Hinduism and became a vegetarian. In 1961, Haldane described India as "the closest approximation to the Free World." Jerzy Neyman objected that "India has its fair share of scoundrels and a tremendous amount of poor unthinking and disgustingly subservient individuals who are not attractive." Haldane retorted:
Perhaps one is freer to be a scoundrel in India than elsewhere. So one was in the U.S.A in the days of people like Jay Gould, when (in my opinion) there was more internal freedom in the U.S.A than there is today. The "disgusting subservience" of the others has its limits. The people of Calcutta riot, upset trams, and refuse to obey police regulations, in a manner which would have delighted Jefferson. I don't think their activities are very efficient, but that is not the question at issue.
No doubt I am in some sense a citizen of the world. But I believe with Thomas Jefferson that one of the chief duties of a citizen is to be a nuisance to the government of his state. As there is no world state, I cannot do this. On the other hand, I can be, and am, a nuisance to the government of India, which has the merit of permitting a good deal of criticism, though it reacts to it rather slowly. I also happen to be proud of being a citizen of India, which is a lot more diverse than Europe, let alone the U.S.A, the U.S.S.R or China, and thus a better model for a possible world organisation. It may of course break up, but it is a wonderful experiment. So, I want to be labeled as a citizen of India.
Haldane wed twice, to respectively Charlotte Franken in 1926 and Helen Spurway in 1945.
Shortly before his death from cancer, Haldane wrote a comic poem while in the hospital, mocking his own incurable disease. It was read by his friends, who appreciated the consistent irreverence with which Haldane had lived his life. He died in Bhubaneshwar, India on December 1, 1964. The poem first appeared in print on 21 February 1964 issue of the New Statesman, and runs:
Cancer's a Funny Thing:
I wish I had the voice of Homer
To sing of rectal carcinoma,
This kills a lot more chaps, in fact,
Than were bumped off when Troy was sacked ...
The poem ends:
... I know that cancer often kills,
But so do cars and sleeping pills;
And it can hurt one till one sweats,
So can bad teeth and unpaid debts.
A spot of laughter, I am sure,
Often accelerates one's cure;
So let us patients do our bit
To help the surgeons make us fit.
My body has been used for both purposes during my lifetime and after my death, whether I continue to exist or not, I shall have no further use for it, and desire that it shall be used by others. Its refrigeration, if this is possible, should be a first charge on my estate.
Following his father's footsteps, Haldane's first publication was on the mechanism of gaseous exchange by haemoglobin, and he subsequently worked on the chemical properties of blood as a pH buffer. He investigated several aspects of kidney functions and mechanism of excretion.
With his sister Naomi Mitchison, Haldane started investigating Mendelian genetics in 1908, used guinea pigs and mice, publishing Reduplication in mice in 1915 the first demonstration of genetic linkage in mammals, showing that certain genetic traits tend to be inherited together (as was later discovered, because of their proximity on chromosomes). As the paper was written during Haldane's service in the First World War, James F. Crow called it "the most important science article ever written in a front-line trench". He was the first to demonstrate linkage in chickens in 1921, and (with Julia Bell) in humans in 1937.
In 1925, with G.E. Briggs, Haldane derived a new interpretation of the enzyme kinetic law of Victor Henri in 1903, better known as the 1913 Michaelis-Menten equation. Leonor Michaelis and Maud Menten assumed that enzyme (catalyst) and substrate (reactant) are in fast equilibrium with their complex, which then dissociates to yield product and free enzyme. By contrast, at almost the same time, Donald Van Slyke and G. E. Cullen treated the binding step as an irreversible reaction. The Briggs-Haldane equation was of the same algebraic form as both of the earlier equations, but their derivation is based on the quasi-steady state approximation, which is the concentration of intermediate complex (or complexes) does not change. As a result, the microscopic meaning of the "Michaelis Constant" (Km) is different. Although commonly referring to it as Michaelis-Menten kinetics, most of the current models typically use the Briggs-Haldane derivation.
In his essay On Being the Right Size he outlines Haldane's principle, which states that the size very often defines what bodily equipment an animal must have: "Insects, being so small, do not have oxygen-carrying bloodstreams. What little oxygen their cells require can be absorbed by simple diffusion of air through their bodies. But being larger means an animal must have complicated oxygen pumping and distributing systems to reach all the cells." The conceptual metaphor to animal allometry has been of use in energy economics and secession ideas.
Origin of life
Haldane introduced the modern concept of abiogenesis in an eight-page article titled The origin of life, in the Rationalist Annual in 1929, describing the primitive ocean as a "vast chemical laboratory" containing a mixture of inorganic compounds - like a "hot dilute soup" in which organic compounds could have formed. Under the solar energy the anoxic atmosphere containing carbon dioxide, ammonia and water vapour gave rise to a variety of organic compounds, "living or half-living things". The first molecules reacted with one another to produce more complex compounds, and ultimately the cellular components. At some point a kind of "oily film" was produced that enclosed self-replicating nucleic acids, thereby becoming the first cell. J. D. Bernal named the hypothesis biopoiesis or biopoesis, the process of living matter spontaneously evolving from self-replicating but lifeless molecules. Haldane further hypothesised that viruses were the intermediate entities between the prebiotic soup and the first cells. He asserted that prebiotic life would have been "in the virus stage for many millions of years before a suitable assemblage of elementary units was brought together in the first cell." The idea was generally dismissed as "wild speculation".Alexander Oparin had suggested a similar idea in Russian in 1924 (published in English in 1936). The hypothesis gained some empirical support in 1953 with the classic Miller-Urey experiment. Since then, the primordial soup theory (Oparin-Haldane hypothesis) has become prevalent in the study of abiogenesis.
Malaria and sickle-cell anemia
In 1949, Haldane proposed that genetic disorders in humans living in malaria-endemic regions provided a phenotype with immunity to blood-borne haemophiles. He noted that mutations expressed in red blood cells, such as sickle-cell anemia and various thalassemias, were prevalent only in tropical regions where malaria has been endemic. He further observed that these were favourable traits for natural selection which protected individuals from receiving malarial infection. This idea was eventually confirmed by Anthony C. Allison in 1954.
His contributions to statistical human genetics included: the first methods using maximum likelihood for the estimation of human linkage maps; pioneering methods for estimating human mutation rates; the first estimates of mutation rate in humans (2 × 10-5 mutations per gene per generation for the X-linked haemophiliagene); and the first notion that there is a "cost of natural selection". At the John Innes Horticultural Institution, he developed the complicated linkage theory for polyploids; and extended the idea of gene/enzyme relationships with the biochemical and genetic study of plant pigments.
A Low cartoon featuring Haldane – "Prophesies for 1949"
In 1938, he proclaimed enthusiastically that "I think that Marxism is true." He joined the Communist Party of Great Britain in 1942. He was pressed to speak out about the rise of Lysenkoism and the persecution of geneticists in the Soviet Union as anti-Darwinist and the political suppression of genetics as incompatible with dialectical materialism. He shifted his polemic focus to the United Kingdom, criticizing the dependence of scientific research on financial patronage. In 1941 he wrote about the Soviet trial of his friend and fellow geneticist Nikolai Vavilov:
The controversy among Soviet geneticists has been largely one between the academic scientist, represented by Vavilov and interested primarily in the collection of facts, and the man who wants results, represented by Lysenko. It has been conducted not with venom, but in a friendly spirit. Lysenko said (in the October discussions of 1939): 'The important thing is not to dispute; let us work in a friendly manner on a plan elaborated scientifically. Let us take up definite problems, receive assignments from the People's Commissariat of Agriculture of the USSR and fulfil them scientifically. Soviet genetics, as a whole, is a successful attempt at synthesis of these two contrasted points of view.'
By the end of the Second World War Haldane had become an explicit critic of the regime. He left the party in 1950, shortly after considering standing for Parliament as a Communist Party candidate. He continued to admire Joseph Stalin, describing him in 1962 as "a very great man who did a very good job".
Social and scientific views
Haldane was the first to have thought of the genetic basis for human cloning, and the eventual artificial breeding of superior individuals. For this he introduced the terms "clone" and "cloning", modifying the earlier "clon" which had been used in agriculture since the early 20th century (from Greek kl?n, twig). He introduced the term in his speech on "Biological Possibilities for the Human Species of the Next Ten Thousand Years" at the Ciba Foundation Symposium on Man and his Future in 1963. He said:
It is extremely hopeful that some human cell lines can be grown on a medium of precisely known chemical composition. Perhaps the first step will be the production of a clone from a single fertilized egg, as in Brave New World...
On the general principle that men will make all possible mistakes before choosing the right path, we shall no doubt clone the wrong people [like Hitler]...
Assuming that cloning is possible, I expect that most clones would be made from people aged at least fifty, except for athletes
and dancers, who would be cloned younger. They would be made from people who were held to have excelled in a socially acceptable accomplishment.
Ectogenesis and in vitro fertilisation
His essay Daedalus; or, Science and the Future (1924) introduced the term ectogenesis for the concept of what is later known as in vitro fertilisation (test tube babies). He envisioned ectogenesis as a tool for creating better individuals (eugenics). Haldane's work was an influence on Huxley's Brave New World (1932) and was also admired by Gerald Heard. Various essays on science were collected and published in a volume titled Possible Worlds in 1927. His book, A.R.P. (Air Raid Precautions) (1938) combined his physiological research into the effects of stress upon the human body with his experience of air raids during the Spanish Civil War to provide a scientific account of the likely effects of the air raids that Britain was to endure during the Second World War.
Criticism of C.S. Lewis
Along with Olaf Stapledon, Charles Kay Ogden, I. A. Richards, and H. G. Wells, Haldane was accused by C. S. Lewis of scientism. Haldane criticised Lewis and his Ransom Trilogy for the "complete mischaracterisation of science, and his disparagement of the human race". Haldane wrote a book for children titled My Friend Mr Leakey (1937), containing the stories "A Meal With a Magician", "A Day in the Life of a Magician", "Mr Leakey's Party", "Rats", "The Snake with the Golden Teeth", and "My Magic Collar Stud"; later editions featured illustrations by Quentin Blake.
In his An Autobiography in Brief, published shortly before his death in India, Haldane named four close associates as showing promise to become illustrious scientists: T. A. Davis, Dronamraju Krishna Rao, Suresh Jayakar and S. K. Roy.
He is famous for the (possibly apocryphal) response that he gave when some theologians asked him what could be inferred about the mind of the Creator from the works of His Creation: "An inordinate fondness for beetles." or sometimes, "....stars and beetles." This is in reference to there being over 400,000 known species of beetles in the world, and that this represents 40% of all known insect species (at the time of the statement, it was over half of all known insect species).
He was often quoted as saying, "My own suspicion is that the universe is not only queerer than we suppose, but queerer than we can suppose."
"It seems to me immensely unlikely that mind is a mere by-product of matter. For if my mental processes are determined wholly by the motions of atoms in my brain I have no reason to suppose that my beliefs are true. They may be sound chemically, but that does not make them sound logically. And hence I have no reason for supposing my brain to be composed of atoms.":209
"Teleology is like a mistress to a biologist: he cannot live without her but he's unwilling to be seen with her in public."
"I had gastritis for about fifteen years until I read Lenin and other writers, who showed me what was wrong with our society and how to cure it. Since then I have needed no magnesia."
"I suppose the process of acceptance will pass through the usual four stages: (i) This is worthless nonsense; (ii) This is an interesting, but perverse, point of view; (iii) This is true, but quite unimportant; (iv) I always said so."
"Three hundred and ten species in all of India, representing two hundred and thirty-eight genera, sixty-two families, nineteen different orders. All of them on the Ark. And this is only India, and only the birds."
"The stupidity of the mynah shows that in birds, as in men, linguistic and practical abilities are not very highly correlated. A student who can repeat a page of a text book may get first class honours, but may be incapable of doing research."
When asked whether he would lay down his life for his brother, Haldane, presaging Hamilton's rule, supposedly replied "two brothers or eight cousins".
second edition (1928), London: Kegan Paul, Trench & Co.
see also Haldane's Daedalus Revisited (1995), ed. with an introd. by Krishna R. Dronamraju, Foreword by Joshua Lederberg; with essays by M. F. Perutz, Freeman Dyson, Yaron Ezrahi, Ernst Mayr, Elof Axel Carlson, D. J. Weatherall, N. A. Mitchison and the editor. Oxford University Press. ISBN0-19-854846-X
Why Professional Workers should be Communists (1945), London: Communist Party (of Great Britain) In this four page pamphlet, Haldane contends that Communism should appeal to professionals because Marxism is based on the scientific method and Communists hold scientists as important; Haldane subsequently disavowed this position.
Adventures of a Biologist (1947)
Science Advances (1947), Macmillan
What is Life? (1947), Boni and Gaer, 1949 edition: Lindsay Drummond
Everything Has a History (1951), Allen & Unwin--Includes "Auld Hornie, F.R.S."; C.S. Lewis's "Reply to Professor Haldane" is available in "On Stories and Other Essays on Literature," ed. Walter Hooper (1982), ISBN0-15-602768-2.
"The Origins of Life", New Biology, 16, 12-27 (1954). Suggests that an alternative biochemistry could be based on liquid ammonia.
^Clarke, Arthur C. (2009). "Foreword". In John Burdon Sanderson Haldane (ed.). What I Require From Life: Writings on Science and Life from J.B.S. Haldane. Oxford: Oxford University Press. p. ix. ISBN978-0-19-923770-8. Archived from the original on 8 March 2017.
^"Haldane on Fast: Insult by USIS Alleged," Times of India, 19 January 1961; "Protest Fast by Haldane: USIS's "Anti-Indian Activities," Times of India, 18 January 1961; "Situation was Misunderstood, Scholars Explain," Times of India, 20 January 1961; "USIS Explanation does not satisfy Haldane: Protest fast continues," Times of India, 18 January 1961; "USIS Claim Rejected by Haldane: Protest Fast to Continue," Times of India, 18 January 1961; "Haldane Not Satisfied with USIS Apology: Fast to Continue," Free Press Journal, 18 January 1961; "Haldane Goes on Fast In Protest Against U.S. Attitude," Times of India, 18 January 1961; "Haldane to continue fast: USIS explanation unsatisfactory," Times of India, 19 January 1961; "Local boy in hunger strike row," Toronto Star, 20 January 1961; "Haldane, Still on Fast, Loses Weight: U.S.I.S. Act Termed 'Discourteous'," Indian Express, 20 January 1961; "Haldane Slightly Tired on Third Day of Fast," Times of India, 21 January 1961; "Haldane Fasts for Fourth Consecutive Day," Globe and Mail, 22 January 1961
^Botting, Gary (1984). "Preface". In Heather Denise Harden; Gary Botting (eds.). The Orwellian World of Jehovah's Witnesses. Toronto: University of Toronto Press. p. xvii. ISBN978-0-8020-6545-2. Archived from the original on 12 March 2017.
^L.M.Cook and J.R.G.Turner 2020 Fifty percent and all that: what Haldane actually said. Biological Journal of the Linnean Society 129, 765-771.
^Marvin, Stephen (2012). Dictionary of Scientific Principles. Chicester: John Wiley & Sons. p. 140. ISBN978-1-118-58224-4.
^Putting science and engineering at the heart of Government policy : eighth report of session 2008-09. 1. London: The Stationery Office: Great Britain: Parliament: House of Commons: Innovation, Universities, Science and Skills Committee. 2009. p. 40. ISBN978-0-215-54034-8.
^Allison, AC (1954). "The distribution of the sickle-cell trait in East Africa and elsewhere, and its apparent relationship to the incidence of subtertian malaria". Transactions of the Royal Society of Tropical Medicine and Hygiene. 48 (4): 312-8. doi:10.1016/0035-9203(54)90101-7. PMID13187561.
^"Mr. Wells' Apocalypse" by Gerald Heard. The Nineteenth Century, October 1933. Reprinted in The H. G. Wells Scrapbook by Peter Haining. London : New English Library, 1978. ISBN0-450-03778-9 (pp. 108-114).
^Adams, Mark B., "The Quest for Immortality: Visions and Presentiments in Science and Literature", in Post, Stephen G., and Binstock, Robert H., The Fountain of Youth: Cultural, Scientific, and Ethical Perspectives on a Biomedical Goal. Oxford University Press, 2004; ISBN0-19-517008-3 (p. 57-58).