Jeffery A. Cook was born in Fort Payne, Alabama, and is of English and Native American descent, Cook is a graduate of Fort Payne High School and Jacksonville State University. He obtained a broadcast engineer license three days after his fourteenth birthday, and worked at a local radio station as a disc jockey while still in high school.
Cook co-founded the band Wildcountry, along with his cousins Randy Owen and Teddy Gentry, in 1972 (the name was changed to Alabama in 1977). He contributed vocals, lead guitar, keyboard, and fiddle to the group's productions. Since Alabama ceased active production and performance in 2003, Cook has formed the groups Cook & Glenn and the Allstar Goodtime Band, with which he performs.
In addition to his performance work, Cook founded Cook Sound Studios, Inc., in his native Fort Payne, and also established radio station WQRX-AM, which he later sold, in adjacent Valley Head, Alabama. Cook is also noted for his culinary endeavors, having operated a restaurant and marketed his own sauce.
Cook is still going on tour but when he is not, he is a part of the Del Chouch Music Education Foundation. On April 11, 2017, Cook disclosed that he was diagnosed with Parkinson's four years ago and will no longer be touring regularly with Alabama. He will still be a part of the band as he stated that he doesn't want to give up music.