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Bowe was born in Greasby, on the Wirral in Cheshire, England. His highest profile role was probably that of George Marlow in the first Prime Suspect serial in 1991. He also played Duggie Ferguson in Coronation Street from 1999 to 2002, having previously appeared in another of Granada TV's soap operas, Families.
Other TV credits include: Warship, Secret Army, Boon, The New Statesman, Capital City, Class Act, Lovejoy, Silent Witness, The Royal, Dalziel and Pascoe, Cleopatra and Einstein and Eddington, Tipping the Velvet, The Hour and DCI Banks and Soldier Soldier. Film credits include The Living Daylights (1987), Resurrected (1989), County Kilburn (2000) and Gozo (2015).
In 2007, Bowe played Dr Morgan in the BBC series Cranford.
In April 2010, Bowe joined the cast of London's West End production Priscilla, Queen of the Desert - The Musical, playing the part of Bob. In September 2011, he appeared as Judge Turpin in Sweeney Todd at Chichester, a role he continued in the West End transfer.
In September 2014, Bowe joined the cast of Emmerdale, playing Lawrence White, the former lover of Harold Birch, the husband of Edna Birch (Shirley Stelfox). He arrived with his daughter Chrissie (Louise Marwood), his grandson Lachlan (Thomas Atkinson) and Chrissie's fiancé, Robert Sugden (Ryan Hawley), who he openly despises. Bowe's departure from Emmerdale was announced in April 2017, however he did not leave until January 2018, when his character was killed off in a car accident.
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