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The John Rankin Lock (formerly named Lock D) is part of the Tennessee-Tombigbee Waterway (popularly known as the Tenn-Tom). It is located in Itawamba County, Mississippi, approximately 6 miles (9.7 km) north of Fulton.
The lock is part of a series of five locks within a stretch of the Tenn-Tom known as the "Chain of Lakes" or "Canal" section. The lock has a lift of 30 feet.
Formerly known simply as Lock D, the lock was later renamed for John E. Rankin, a former Mississippi First District Representative in the United States House of Representatives and an early champion of the Tenn-Tom.