He was born in Tacuarembó, Uruguay. He received a professional degree in Architecture in 1996 from the University of the Republic in Montevideo and studied at Escuela Nacional de Bellas Artes. He traveled extensively to gather material that would later become part of his novels and essays and was a professor at the Universidad Hispanoamericana of Costa Rica and at Escuela Técnica del Uruguay, where he taught art and mathematics.
In 2003 he entered the University of Georgia, where he obtained a Masters and a Ph.D. in the Department of Romance Languages. He is a member of the scientific committee of the Araucaria review of Spain, The Honor Society of Phi Kappa Phi, and a Professional Member of PEN American Center. He taught at the University of Georgia and was a professor at Lincoln University in Pennsylvania. Currently, he is a professor at Jacksonville University.
Dr. Majfud has won many research awards including the Excellence in Research Award in Humanities and Letters 2006, Casa de las Américas prize 2001, Juan Rulfo Award finalist 2011, and Faculty Award for Excellence in Scholarship and Professional Activities, Jacksonville University, 2013.
His novels and essays are under study in different universities in Europe, the U.S., and Latin America. "He is one of the most important writers of a new generation of Latino intellectuals". In 2012, readers of the American magazine Foreign Policy (now EsGlobal in Spanish) recognized him as "The Most Influential Latin American Intellectual" 
His publications include:
Hacia qué patrias del silencio / memorias de un desaparecido (novel, 1996)
His essays and articles have been translated into Portuguese, French, English, German, Italian, Basque, Greek, and many others. He is also the editor and translator of Ilusionistas, the latest book of Noam Chomsky in Spanish (Madrid, 2012).
He has distinguished himself in different international contests, for example:
Mention at Premio Casa de las Américas, in Habana, Cuba in 2001, for the novel La Reina de América, "because it stands out as an intense writing regarding the established powers by the use of parody and irony," according to the panel of judges composed of Belén Gopegui (Spain), Andrés Rivera (Argentina), Mayra Santos Febres (Puerto Rico) and others
Excellence in Research Award, University of Georgia, 2006
Faculty Award for Excellence in Scholarship and Professional Activities, Jacksonville University, 2013.
2014 International Latino Book Awards Finalist
Ferrer Herrero, Raúl. El otro en Jorge Majfud. Madrid: Ediciones Irreverentes, 2017 
Taiano, Leonor. De un infierno a otro: El migrante latino en Crisis de Jorge Majfud Rio: Universidade do Estado do Rio de Janeiro Press, 2018 
Taiano, Leonor. Finisterre: en el últimolugar del mundo. "Huyendo hacia la paradoja del tío Sam: Consideraciones sobre Crisis de Jorge Majfud" (123-148) 
Gianni, Silvia M. "Identidad de la ausencia", University of Milan.(117-122)