Spiegel worked at CBS on 60 Minutes, the CBS Morning News and the CBS Evening News. She was a producer in the New York, London, and Central America bureaus. In 1995, she was a bureau chief in Beirut.
In January 2015, Spiegel left CNN after working as executive director for contributors and audience for six years. Spiegel has overseen network commentators, such as Jesse Jackson, James Carville, Mary Matalin, Jay Carney, Ana Navarro, and Donna Brazile.
In 2009, she was the nominee, with other, for the Emmy "Outstanding Live Coverage of a Breaking News Story - Long Form" for her work on the TV presentation "CNN Election Night in America 2008".