Melitidin
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Melitidin
Melitidin
Melitidin.png
Names
IUPAC name
5-[[(2R,3S,4S,5R,6S)-3,4-dihydroxy-6-[5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-2,3-dihydrochromen-7-yl]-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]methoxy]-3-hydroxy-3-methyl-5-oxopentanoic acid
Identifiers
3D model (JSmol)
Properties
C33H40O18
Molar mass  g·mol-1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Melitidin is a flavanone glycoside. Melitidin was discovered in bergamot orange juice and exhibits statin-like properties[1][2] so the juice seems to have hypolipidemic activity.[1][3][4][5]

See also

References

  1. ^ a b Di Donna, Leonardo; De Luca, Giuseppina; Mazzotti, Fabio; Napoli, Anna; Salerno, Raffaele; Taverna, Domenico; Sindona, Giovanni (2009). "Statin-like Principles of Bergamot Fruit: Isolation of 3-Hydroxymethylglutaryl Flavonoid Glycosides". Journal of Natural Products. 72 (7): 1352-1354. doi:10.1021/np900096w. PMID 19572741.
  2. ^ Di Donna, Leonardo; Gallucci, Giselda; Malaj, Naim; Romano, Elvira; Tagarelli, Antonio; Sindona, Giovanni (2011). "Recycling of industrial essential oil waste: Brutieridin and Melitidin, two anticholesterolaemic active principles from bergamot albedo". Food Chemistry. 125 (2): 438-441. doi:10.1016/j.foodchem.2010.09.025. ISSN 0308-8146.
  3. ^ Natalizia Miceli; M. R. Mondello; M. T. Monforte; V. Sdrafkakis; P. Dugo; M. L. Crupi; M. F. Taviano; R. De Pasquale; A. Trovato (2007). "Hypolipidemic Effects of Citrus bergamia Risso et Poiteau Juice in Rats Fed a Hypercholesterolemic Diet". J. Agric. Food Chem. 55 (27): 10671-10677. doi:10.1021/jf071772i.
  4. ^ Monica Leopoldini; N. Malaj; M. Toscano; G. Sindona & N. Russo (2010). "On the Inhibitor Effects of Bergamot Juice Flavonoids Binding to the 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGR) Enzyme". J. Agric. Food Chem. 58 (19): 10768-10773. doi:10.1021/jf102576j.
  5. ^ Vincenzo Mollace; I. Sacco; E. Janda; C. Malara; D. Ventrice; C. Colica; V. Visalli; S. Muscoli; S. Ragusa; C. Muscoli; D. Rotirotia; F. Romeo (2011). "Hypolipemic and hypoglycaemic activity of bergamot polyphenols: From animal models to human studies". Fitoterapia. 82 (3): 309-316. doi:10.1016/j.fitote.2010.10.014. PMID 21056640.PDF Archived 2012-04-02 at the Wayback Machine

Bibliography

  • Zou, W; Wang Y; Liu H; Luo Y; Chen S; Su W (2013). "Melitidin: a flavanone glycoside from Citrus grandis 'Tomentosa'". Nat Prod Commun. 8 (4): 457-458. PMID 23738451.
  • Mencherini, Teresa; Campone, Luca; Piccinelli, Anna Lisa; García Mesa, Milagros; Sánchez, Dulce María; Aquino, Rita Patrizia; Rastrelli, Luca (2013). "HPLC-PDA-MS and NMR Characterization of a Hydroalcoholic Extract of Citrus aurantium L. var.amara Peel with Antiedematogenic Activity". Journal of Agricultural and Food Chemistry. 61 (8): 1686-1693. doi:10.1021/jf302815t. ISSN 0021-8561.
  • Barreca, Davide; Bellocco, Ersilia; Caristi, Corrado; Leuzzi, Ugo; Gattuso, Giuseppe (2011). "Distribution of C- and O-glycosyl flavonoids, (3-hydroxy-3-methylglutaryl)glycosyl flavanones and furocoumarins in Citrus aurantium L. juice". Food Chemistry. 124 (2): 576-582. doi:10.1016/j.foodchem.2010.06.076. ISSN 0308-8146.
  • Di Donna, Leonardo; Taverna, Domenico; Mazzotti, Fabio; Benabdelkamel, Hicham; Attya, Mohamed; Napoli, Anna; Sindona, Giovanni (2013). "Comprehensive assay of flavanones in citrus juices and beverages by UHPLC-ESI-MS/MS and derivatization chemistry". Food Chemistry. 141 (3): 2328-2333. doi:10.1016/j.foodchem.2013.05.034. ISSN 0308-8146.

External links

  • Media related to Melitidin at Wikimedia Commons



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Melitidin
 



 



 
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