Mesh-ki-ang-gasher (Mè?-ki-á?-ga-?e-er, Me?-ki-a?-ga?er; also transliterated Mes-Kiag-Gasher, Mesh-Ki-Ang-Gasher, Meskiagkasher, Meckiagkacer and variants) was a Sumerian ruler and the founder of the First Dynasty of Uruk and the father of Enmerkar, according to the Sumerian king list. If a historical ruler, he would have flourished in ca. the 28th century BC (Early Bronze Age II).
E-ana ("house of heaven") was the name of the temple to Inanna at Uruk. The entry thus has Mesh-ki-ang-gasher ruling the fortress or castle around which his son would build the city of Uruk, and which was to become the main temple to its patron goddess.
Unlike his successors Enmerkar, Lugalbanda, Dumuzid, the Fisherman and Gilgamesh, Mesh-ki-ang-gasher is not known from Sumerian epics or legends besides the King List. His nature as the son of the sun god, the founder of a major dynasty and his mysterious "disappearance" in the sea give him a mostly mythological flavour. His son Enmerkar is also called "son of Utu" in the Sumerian legend Enmerkar and the Lord of Aratta — where, aside from founding Uruk, Enmerkar is credited with building a temple at Eridu and with the invention of writing.