"No Scrubs" was met with international success. It became TLC's third number-one single and eighth top 10 single on the Billboard Hot 100. It also earned them their second Grammy Award nomination for Record of the Year. "No Scrubs" is one of TLC's signature songs and was the second-biggest Hot 100 single of 1999 in the U.S., only behind Cher's "Believe", according to Billboards year-end charts. On the decade end chart for 1990-99, "No Scrubs" was ranked at number 33. The single was certified 2× Platinum in the UK and Platinum in New Zealand.
In 1999, "No Scrubs" was listed on The Village Voices annual poll Pazz & Jop at number one. The song also came in at number two in the NME Top Tracks of 1999 and number 45 in the NME 100 Best Songs of the 1990s.Rolling Stone ranked the song at number 10 in their list of the 50 Best Songs of the Nineties. Additionally, VH1 listed the song at number 22 in their list of the 40 Greatest R&B Songs of the 90s, ranking behind TLC's 1995 international smash "Waterfalls" which placed at number 6.Billboard named the song #42 on their list of 100 Greatest Girl Group Songs of All Time.
"No Scrubs" climbed into the U.S. top ten as an airplay only song and jumped to number one upon the single release. The single stayed at number one on the Billboard Hot 100 for four weeks from April 10, 1999, to May 7, 1999. The single stayed in the top-10 of the Billboard Hot 100 for 17 consecutive weeks. "No Scrubs" airplay was at the time astonishing; it was the first song to peak with over 140 million audience impressions and was crowned the Top Airplay Song of 1999. It holds the record for most weeks at number 1 on the Rhythmic Top 40 with 15 weeks.
In Australia, "No Scrubs" was a huge success, spending seven consecutive weeks at the summit of the Australian Singles Chart from May 2, 1999 to June 20, 1999.
The futuristic music video, directed by Hype Williams, received massive airplay on MTV and BET, and won the group the 1999 MTV Video Music Award for Best Group Video, beating out favorites NSYNC and the Backstreet Boys. Each member had a set in the video. The video also has a dance sequence where the women dance in front of the "TLC" logo. The Main Mix is used in the video instead of the album version.
The video features the women in three different outfits: white, black, silver and Left Eye in blue. When there are shots of the women together they have two different outfits: black and silver. T-Boz's hair is fuchsia in the video. It also features a scene of Chilli on a swing singing. It also features T-Boz dancing as well as Left Eye. As Left Eye's rap begins, she is in a garage-like place with white clothes on while rapping. It also shows her practicing fighting moves in a futuristic blue outfit. One of the final scenes shows TLC fighting each other, while also dancing and having fun. The video is stylistically similar to Michael Jackson and Janet Jackson's music video "Scream".
^Pietroluongo, Silvio; Patel, Minal; Jessen, Wade (January 19, 2002). "Singles Minded". Billboard. 114 (3): 77. ISSN0006-2510. Retrieved 2018. The record now reverts to Arista, which was the first label to surpass the 140 million audience mark in May 1999 with TLC's 'No Scrubs.'
^Pietroluongo, Silvio; Patel, Minal; Jessen, Wade (January 12, 2002). "Singles Minded". Billboard. 114 (2): 83. ISSN0006-2510. Retrieved 2018. In two prior years, only TLC's 'No Scrubs' in 1999 topped the 140-million listener mark, but three had such weeks in 2001's chart year, including 'Independent Women.'