is the experimental science of determining the arrangement of atoms in crystalline solids (see crystal structure
). The word "crystallography" is derived from the Greek
"cold drop, frozen drop", with its meaning extending to all solids with some degree of transparency, and graphein
"to write". In July 2012, the United Nations
recognised the importance of the science of crystallography by proclaiming that 2014 would be the International Year of Crystallography. X-ray crystallography
is used to determine the structure of large biomolecules
such as proteins
Before the development of X-ray diffraction crystallography (see below), the study of crystals
was based on physical measurements of their geometry. This involved measuring the angles of crystal faces relative to each other and to theoretical reference axes (crystallographic axes), and establishing the symmetry
of the crystal in question. This physical measurement is carried out using a goniometer
. The position in 3D space of each crystal face is plotted on a stereographic net such as a Wulff net
or Lambert net
. The pole
to each face is plotted on the net. Each point is labelled with its Miller index
. The final plot allows the symmetry of the crystal to be established.
Crystallographic methods now depend on analysis of the diffraction
patterns of a sample targeted by a beam of some type. X-rays
are most commonly used; other beams used include electrons
. This is facilitated by the wave properties of the particles. Crystallographers often explicitly state the type of beam used, as in the terms X-ray crystallography, neutron diffraction
and electron diffraction
. These three types of radiation interact with the specimen in different ways.
Because of these different forms of interaction, the three types of radiation are suitable for different crystallographic studies. Read more...