Pudu?epa was born at the beginning of the 13th century BC in the city of Lawazantiya in Kizzuwatna (i.e. Cilicia, a region south of the Hittite kingdom). Her father Bentepsharri was the head priest of the tutelary divinity of the city, Ishtar, and Pudu?epa grew up to exercise the function of priestess of this same goddess.
On his return from the Battle of Kadesh, the Hittite general Hattusili met Pudu?epa and, it was said, Ishtar instructed him to take her as his wife, decreeing that they would enjoy the 'love of husband and wife.' She went with him then to the kingdom of Hapissa. For Pudu?epa it was an advantageous match. Although Hattusili was most likely much older than her and already had numerous wives and concubines, Pudu?epa became first among his wives. When her spouse successfully rose to the Hittite throne by defeating his nephew Mursili III in a civil war instigated by Hattusili around 1286 BC, Pudu?epa ascended the throne with him, becoming tawananna, or queen.
Pudu?epa had an important role in the Hittite court and international diplomacy of the period. She would appear constantly by the side of her husband as he made his rulings and decisions. It appears, however, that she was portrayed reigning hand in hand with her husband rather than subservient to the king. Pudu?epa had the use of her own seal, controlled the domestic arrangements of the royal palaces, and judged court cases. Blending religion and politics, she reorganized the vast pantheon of Hittite deities.
From the royal palace in the newly rebuilt capital city of Hattusa, Pudu?epa used her sons and daughters to ensure Hittite ascendancy and to cement alliances. This was a role that had never been performed by a Hittite queen before.
She played an important role in diplomacy with Ancient Egypt. Extensive correspondence bearing Pudu?epa's seal survives, communicating several times with the king of EgyptRamesses II as he signed a peace treaty with Hattusili, in which Hattusili agrees that two of his daughters should go to Egypt to marry Ramesses.
A diplomatic marriage between King Kadashman-Enlil II of Babylonia may have been in the offing with Pudu?epa matchmaking Kadashman-Enlil's betrothal to one of her daughters.
After the death of Hattusili, the role of Pudu?epa expanded under the reign of her son Tudhaliya IV, under the title of goddess-queen. She was involved in judicial matters to the point of intervening in legal cases. She was also a priestess who worked on organising and rationalising Hittite religion.
The great Queen Naptera (Nefertari) of the land of Egypt speaks thusSpeak to my sister Pudu?epa, the Great Queen of the Hatti land. I, your sister, (also) be well!! May your country be well. Now, I have learned that you, my sister, have written to me asking after my health. You have written to me because of the good friendship and brotherly relationship between your brother, the king of Egypt, The Great and the Storm God will bring about peace, and he will make the brotherly relationship between the Egyptian king, the Great King, and his brother, the Hatti King, the Great King, last for ever... See, I have sent you a gift, in order to greet you, my sister... for your neck (a necklace) of pure gold, composed of 12 bands and weighing 88 shekels, coloured linen maklalu-material, for one royal dress for the king... A total of 12 linen garments.'
^King (lugal) of Tarhuntassa (Bryce 1997, p. 296); apparently later Great King of Hatti (Bryce 1997, p. 354).
^Nerikkaili married a daughter of Bentesina, king of Amurru (Bryce 1997, p. 294).
^Two daughters of Hattusili III were married to the pharaoh Ramesses II; one was given the Egyptian name Ma(hor)nefrure. Another, Gassuwaliya, married into the royal house of Amurru. Kilushepa was married to a king of Isuwa. A daughter married into the royal family of Babylon. A sister of Tudhaliya IV married Sausgamuwa, king of Amurru after his father Bentesina. From Bryce (1997), pp. 294 and 312.