Solubilization
Get Solubilization essential facts below. View Videos or join the Solubilization discussion. Add Solubilization to your PopFlock.com topic list for future reference or share this resource on social media.
Solubilization
Schematic of micellar solubilization of fatty substance in water with the use of a dispersant

Micellar solubilization (solubilization) is the process of incorporating the solubilizate (the component that undergoes solublization) into or onto micelles.[1] Solublization may occur in a system consisting of a solvent, an association colloid (a colloid that forms micelles), and at least one other solubilizate.

Usage of the term

Solubilization is distinct from dissolution because the resulting fluid is a colloidal dispersion involving an association colloid. This suspension is distinct from a true solution, and the amount of the solubilizate in the micellar system can be different (often higher) than the regular solubility of the solubilizate in the solvent.

In non-chemical literature and in everyday language, the term "solubilization" is sometimes used[] in a broader meaning as "to bring to a solution or (non-sedimenting) suspension" by any means, e.g., leaching by a reaction with an acid.

Application

Micellar solubilization is widely utilized, e.g. in laundry washing using detergents, in the pharmaceutical industry, for formulations of poorly soluble drugs in solution form,[2] and in cleanup of oil spills using dispersants.

Mechanism

Literature distinguishes two major mechanisms of solubilization process of oil by surfactant micelles, affecting the kinetics of solubilization:[3] surface reaction, i.e., by transient adsorption of micelles at the water-oil interface, and bulk reaction, whereby the surfactant micelles capture dissolved oil molecules.

See also

References

  1. ^ "micellar solubilization". 2009. doi:10.1351/goldbook.M03887. Cite journal requires |journal= (help)
  2. ^ Jain A, Ran Y, Yalkowsky S, "Effect of pH-Sodium Lauryl Sulfate Combination on Solubilization of PG-300995 (an Anti-HIV Agent): A Technical Note." AAPS PharmSciTech. 2004; 5(3): article 45. [1]
  3. ^ P. D. Todorov, P. A. Kralchevsky, N. D. Denkov, G. Broze, and A. Mehreteab, "Kinetics of Solubilization of n-Decane and Benzene by Micellar Solutions of Sodium Dodecyl Sulfate". Journal of Colloid and Interface Science 245, 371-382 (2002), doi:10.1006/jcis.2001.8031 [2]


External links

Solubilization of Homopolymers by Block Copolymer Micelles in Dilute Solutions, J. Phys. Chem., 1995, 99 (11), pp 3723-3731, Jose R. Quintana, Ramiro A. Salazar, Issa Katime


  This article uses material from the Wikipedia page available here. It is released under the Creative Commons Attribution-Share-Alike License 3.0.

Solubilization
 



 



 
Music Scenes