|Maintained by SCDOT|
|Length||79.49 mi (127.93 km)|
|Western York Scenic Byway|
|South end||in Watts Mills|
|North end||at the North Carolina line in Lake Wylie|
|Counties||Laurens, Spartanburg, Union, Chester, York|
South Carolina Highway 49 (SC 49) is a primary state highway in the U.S. state of South Carolina. It is signed as a north-south highway, though it travels in a southwesterly-northeasterly direction, from Watts Mills to the North Carolina state line in Lake Wylie.
The portion in South Carolina runs miles (127.9 km) from Watts Mills to Lake Wylie.
Established in 1937 as a renumbering of SC 163, it ran from U.S. Route 321 (US 321) in York to the North Carolina state line in Lake Wylie. In 1956, SC 49 was extended southwest to its current southern terminus at US 221 in Watts Mills replacing SC 91 from York to Monarch, SC 92 from Monarch to Cross Anchor, and SC 30 from Cross Anchor to Watts Mills.
One previous SC 49 existed from around 1927-1935, from Myrtle Beach to the North Carolina state line in Little River. In 1932, most of SC 49 north of Myrtle Beach was replaced by US 117; by 1935, the rest of SC 49 (and US 117) was replaced by US 17.
|Laurens||Watts Mills||0.00||0.00||(Lucas Avenue) - Laurens, Woodruff|
|- Columbia, Greenville||I-385 exit 5|
|- Columbia, Spartanburg||I-26 exit 44|
|||10.40||16.74||west - Enoree||Eastern terminus of SC 92|
|Cross Anchor||12.59||20.26||- Woodruff, Clinton|
north / east (Industrial Park Road)
|Southern terminus of SC 49 Truck; western terminus of SC 496|
|28.43||45.75||east / south (Duncan Bypass) / West Main Street - Whitmire||Southern end of US 176 and SC 215 overlap; northern terminus of SC 49 Truck|
|29.18||46.96||west / north (Duncan Bypass) / Rice Avenue - Spartanburg||Northern end of US 176 and SC 215 overlap|
|29.97||48.23||(Thompson Boulevard) - Jonesville, Union|
|||39.01||62.78||north (Mount Tabor Church Road)||Southern terminus of SC 105|
|Lockhart||41.54||66.85||north (Jonesville-Lockhart Highway) - Jonesville||Southern end of SC 9 overlap|
|Chester||||42.25||67.99||south (Pinckney Road)||Northern end of SC 9 overlap|
|York||Bullock Creek||47.48||76.41||east (McConnells Highway) - McConnells||Western terminus of SC 322|
|Sharon||55.94||90.03||north (Hickory Grove Road) - Hickory Grove||Southern terminus of SC 211|
south (Congress Street) - Chester
|Southern end of US 321 Bus. overlap|
/ (Liberty Street)
north (Kings Mountain Street) - Gastonia
|Northern end of US 321 Bus. overlap|
|64.80||104.29||/ - Rock Hill, Blacksburg|
|||74.12||119.28||east (Hands Mill Highway) - Rock Hill||Southern end of SC 274 overlap|
|||74.32||119.61||west - Clover||Eastern terminus of SC 55|
|Lake Wylie||76.37||122.91||west / south - Clover, Gastonia||Northern end of SC 274 overlap; eastern terminus of SC 557|
|79.49||127.93||north (York Road) - Charlotte||North Carolina state line|
|1.000 mi = 1.609 km; 1.000 km = 0.621 mi|
SC 49 Truck is a one-mile-long (1.6 km) truck route that bypasses a portion of West Main Street (SC 49) in western portions of Union. The first mile (1.2 km) of the route runs along the two-lane Industrial Park Road, concurrent with the unsigned SC 496. It then turns to the north along US 176/SC 215 for its last mile (0.40 km).