|Maintained by SCDOT|
|Length||11.90 mi (19.15 km)|
|South end||southwest of Shiloh|
| / in Shiloh|
northeast of Shiloh
|North end||northeast of Shiloh|
SC 53 begins at an intersection with US 378 (Myrtle Beach Highway) southwest of Shiloh, within Sumter County. It travels to the northeast, through rural areas of the county, and curves to a nearly due east direction. It intersects SC 58 (Pleasant Grove Road), and the two highways begin a concurrency. They have an interchange with Interstate 95 (I-95), where they enter Shiloh. Approximately 500 feet (150 m) later, SC 53 splits off to the south, onto Pudding Swamp Road. SC 53 continues through rural areas of the county to an intersection with SC 341 (Mt. Zion Road). About 2,000 feet (610 m) later is the highway's northern terminus, an intersection with SC 403 (Lynches River Road/Amwell Church Road). This is southwest of the Lynches River.
The entire route is in Sumter County.
|(Myrtle Beach Highway) - Turbeville, Sumter|
|||5.95||9.58||west (Pleasant Grove Road) - Lynchburg||Southern end of SC 58 concurrency|
|- Savannah, Florence||I-95 exit 141|
|6.38||10.27||east (Pudding Swamp Road) - Turbeville||Northern end of SC 58 concurrency|
|||11.51||18.52||(Mt. Zion Road) - Lake City, Lynchburg, Bishopville|
|||11.90||19.15||(Lynches River Road/Amwell Church Road) - Lake City, Sardis|
|1.000 mi = 1.609 km; 1.000 km = 0.621 mi|