|Maintained by SCDOT|
|Length||73.2 mi (117.8 km)|
|West end||Savannah River Site|
|East end||in Jacksonboro|
|Counties||Barnwell, Bamberg, Colleton|
South Carolina Highway 64 (SC 64) is a primary state highway in the U.S. state of South Carolina. It serves the cities of Barnwell and Walterboro while also providing a direct route to Charleston, via U.S. Route 17 (US 17).
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SC 64 was established around 1926 as a new primary routing from SC 28 near Ellenton, to SC 6/SC 301 near Ruffin. In 1928, SC 64 was extended east to US 17 in Walterboro, replacing part of SC 6. Around 1930, SC 64 was extended east again on new routing to US 78/SC 2 in Summerville. By 1932, SC 64 was extended east again at US 17 in Moncks Corner. In 1939, all sections of SC 64 were paved.
In 1950, SC 64 was extended in both directions: northeast with a concurrency with SC 28 to SC 781 in Beech Island and east replacing SC 179 to Jamestown, then north in concurrency with SC 511, then east to end at US 521, west of Georgetown. This routing was the apex of SC 64's length at a total of over 181 miles (291 km).
Around 1952, SC 64's routing had a major shake-up. Starting in Aiken and Barnwell counties, where the Savannah River Site was established, roughly 23 miles (37 km) of highway was removed in what is now restricted area. A section of SC 64 remained northwest of the Savannah River Site to Beech Island. East of Walterboro, SC 64 was rerouted to US 17, replacing what was US 17, to its current eastern terminus in Jacksonboro; its old alignment was replaced completely by US 17 Alternate (US 17 Alt.). In 1953, the Beech Island section of SC 64 was renumbered as part of SC 125.
By 1955, SC 64 was widened to a divided four-lane highway from the Savannah River Site to Barnwell. In 1973, SC 64 was widened to a divided four-lane with its concurrency with US 301. In 1976, SC 64 was widened to four lanes between Interstate 95 (I-95) to Walterboro. Between 1983 and 1985, SC 64 was placed on a new bypass going north and east of Walterboro, leaving SC 64 Business (SC 64 Bus.) along its old downtown route.
|Barnwell||Savannah River Site||0.0||0.0||Dunbarton Boulevard||Gate entrance, restricted access|
|Barnwell||6.1||9.8||west (Ellenton Street) - Williston, Aiken, Augusta||West end of US 278 overlap|
|6.4||10.3||east (Allen Street) / Dunbarton Boulevard - Denmark|
|6.7||10.8||east (Jackson Street) - Allendale||East end of US 278 overlap|
|7.2||11.6||(Marlboro Avenue) - Columbia, Allendale||To Barnwell State Park|
|Bamberg||Olar||18.5||29.8||(Dana Street) - Allendale, Fairfax, Denmark, Columbia|
|||20.8||33.5||north (Main Highway) - Bamberg||North end of US 301 overlap|
|||21.1||34.0||south (Main Highway) - Allendale, Fairfax||South end of US 301 overlap|
|Ehrhardt||31.1||50.1||(Broxton Bridge Road) - Hampton, Bamberg|
|Colleton||Lodge||35.1||56.5||east (Lodge Highway) - Smoaks, Ashton|
|||37.8||60.8||west (Confederate Highway)||To Rivers Bridge State Park|
|||43.6||70.2||north (Williams Road) - Williams|
|Bells Crossroads||44.2||71.1||(Low Country Highway) - Yemassee, Branchville|
|Walterboro||54.5||87.7||- Savannah, Florence||I-95 exit 57|
east (Bells Highway)
|To Artisan Center|
|56.2||90.4||(Jefferies Boulevard) - St. George|
(Whichman Street) - Summerville
|To Lowcountry Regional Airport and Tuskegee Airmen Monument|
west (Hampton Street) to west - Savannah
|To USC Salkehatchie|
|Jacksonboro||73.2||117.8||- Savannah, Charleston|
|1.000 mi = 1.609 km; 1.000 km = 0.621 mi|
|Location||Walterboro, South Carolina|
|Length||2.7 mi (4.3 km)|
SC 64 Business (SC 64 Bus.) was established between 1983-1985 when mainline SC 64 was bypassed north and east of Walterboro. It follows the original mainline route through downtown Walterboro, via Bells Highway, Jeffries Boulevard, Paul Street, Wichman Street, Padgett Loop and Hampton Street.