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As of the 2010 United States Census, there were 284,307 people, 109,246 households, and 75,404 families residing in the county. The population density was 351.9 inhabitants per square mile (135.9/km2). There were 122,628 housing units at an average density of 151.8 per square mile (58.6/km2). The racial makeup of the county was 72.3% white, 20.6% black or African American, 2.0% Asian, 0.3% American Indian, 3.1% from other races, and 1.7% from two or more races. Those of Hispanic or Latino origin made up 5.9% of the population. In terms of ancestry, 13.6% were American, 10.5% were Irish, 9.6% were English, and 8.8% were German.
Of the 109,246 households, 34.3% had children under the age of 18 living with them, 48.9% were married couples living together, 15.1% had a female householder with no husband present, 31.0% were non-families, and 26.2% of all households were made up of individuals. The average household size was 2.53 and the average family size was 3.05. The median age was 38.0 years.
The median income for a household in the county was $42,680 and the median income for a family was $53,149. Males had a median income of $41,445 versus $31,602 for females. The per capita income for the county was $21,924. About 11.0% of families and 14.8% of the population were below the poverty line, including 20.5% of those under age 18 and 10.9% of those age 65 or over.
Spartanburg County is served by the Spartanburg County School System, which is divided into seven districts. Some of the districts share a vocational school, and also share the McCarthy Teszler School, a special education school.
School District One includes Campobello-Gramling, Chapman High School, Holly Springs-Motlow Elementary, Inman Elementary, Inman Intermediate, Landrum High, Landrum Middle, Mabry Middle, New Prospect Elementary, and O.P. Earle Elementary. District One students can also attend Swofford Career Center
School District Two includes Boiling Springs Elementary, Cooley Springs-Fingerville Elementary, Chesnee Elementary, Hendrix Elementary, Carlisle-Foster's Grove Elementary, Mayo Elementary, Oakland Elementary, Boiling Springs Intermediate, Boling Springs Junior High, Rainbow Lake Middle School, Chesnee Middle School, Boiling Springs High 9th grade, Boiling Springs High School, and Chesnee High School. District Two students can also attend Swofford Career Center.
School District Three includes Cannons Elementary, Clifdale Elementary, Cowpens Elementary School, Pacolet Elementary School, Cowpens Middle School, Middle School of Pacolet, and Broome High School. District Three students can attend the Daniel Morgan Technology Center.
School District Four has four schools: Woodruff Primary, Woodruff Elementary, Woodruff Middle and Woodruff High School. High school students also can attend R.D. Anderson Applied Technology Center to learn vocational skills.
School District Five consists of Abner Creek Academy (formerly Abner Creek Elementary), Duncan Elementary, Lyman Elementary, Reidville Elementary, River Ridge Elementary, Wellford Academy of Science and Technology (formerly Wellford Elementary), Beech Springs Intermediate, Berry Shoals Intermediate, D. R. Hill Middle, Florence Chapel Middle, James F. Byrnes Freshman Academy, and James F. Byrnes High School. Vocational school students can attend R. D. Anderson Applied Technology Center.
School District Six comprises Anderson Mill Elementary, Arcadia Elementary, Jesse S. Bobo Elementary, Fairforest Elementary, Lone Oak Elementary, Pauline-Glenn Springs Elementary, Roebuck Elementary, West View Elementary, Woodland Heights Elementary, Fairforest Middle, R. P. Dawkins Middle, L. E. Gable Middle, Dorman Freshman Campus, and Paul M. Dorman High School. District Six students can attend R. D. Anderson Applied Technology Center.
School District Seven consists of Jesse Boyd Elementary, Chapman Elementary, Cleveland Elementary, Houston Elementary, Park Hills Elementary, Pine Street Elementary, Mary H. Wright Elementary, Edwin P. Todd School, George Washington Carver Middle, Joseph G. McCracken Middle, Whitlock Junior High, Spartanburg High School Freshman Academy, and Spartanburg High School. The Daniel Morgan Technology Center, ZL Madden Learning Center, The Myles W. Whitlock Flexible Learning Center, and The Early Learning Center at Park Hills also serve District Seven.
Spartanburg County's healthcare is mainly provided by Spartanburg Regional Healthcare System. Spartanburg Regional is a public, not-for-profit, integrated health care delivery system with several facilities in Spartanburg, including:
Spartanburg Medical Center (SMC), a research and teaching hospital with two locations: Spartanburg Medical Center campus on East Wood Street and Spartanburg Medical Center -- Mary Black Campus on Skylyn Drive. Together, these campuses share a history that stretches back to the 1920s. Spartanburg Medical Center includes a total of 747 beds, and services that include emergency, surgical, maternity, cancer, a Heart Center and inpatient rehabilitation.
Pelham Medical Center, in Greer, S.C., provides emergency services, general surgery, a medical office building and numerous practices.
Spartanburg Hospital for Restorative Care (SHRC), a 97-bed long-term, acute-care hospital with a 25-bed skilled nursing facility.
Gibbs Cancer Center & Research Institute, providing an inpatient oncology unit and outpatient care, along with access to clinical trials and the latest cancer technology. With locations across Upstate S.C., including Spartanburg and Greer in Spartanburg County.
Bearden-Josey Center for Breast Health, a state-of-the-art imaging center for digital mammography, ultrasound, stereotactic breast biopsy and bone densitometry.
Medical Group of the Carolinas, a physician group with offices located throughout Spartanburg and Upstate S.C.
Regional HealthPlus (RHP), a network of hospitals and physicians of every specialty
Woodruff Manor, an 88-bed skilled nursing and rehabilitation facility in Woodruff, S.C.
The Sports Medicine Institute, located at Upward Star Center, where doctors, athletic trainers physical therapists serve professional and recreational athletes 
Cancer care expansion
In early 2018, Spartanburg Regional began construction on an expansion of its Gibbs Cancer Center & Research Institute at Pelham location. The 190,000-square-foot expansion is intended to provide cancer care for more patients along the border of Spartanburg and Greenville counties. It is anticipated that the construction will be completed in spring 2020.