The group was founded as a gospel group in 1947 under the name Zion City Harmonizers, and later sang as the Delta Southernaires, recording and performing on radio under the latter name in 1952-53.Cosimo Matassa convinced them to begin singing secular music, and in 1953 the five-piece, based around brothers Hayward "Chuck" Carbo (1926–2008) and Leonard "Chick" Carbo (1927–1998), signed with Imperial Records, under the name The Spiders. They had several U.S. hits on the R&B chart in the middle of the decade, including their first single "I Didn't Want to Do It" (R&B #3, 1954), "I'm Slippin' In" (R&B #6, 1954), "21" (R&B #9, 1955), and "Witchcraft" (R&B #5, 1956). The latter was co-written by Dave Bartholomew and was later covered by Elvis Presley.
Members Joe Maxon and Matthew West left the group in 1955 and were replaced by Issacher Gordon and Bill Moore. Chick Carbo signed with Atlantic Records as a solo artist late in 1956, and by the next year the group had splintered; their last single as a group was 1957's "That's My Desire", though the song "Tennessee Slim", recorded in the middle of the decade, was issued as a single in 1960.