Tinactin
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Tinactin
Tolnaftate
Tolnaftate.svg
Clinical data
Trade namesTinactin
Synonyms2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate[1]
AHFS/Drugs.comMonograph
MedlinePlusa682617
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.017.516 Edit this at Wikidata
Chemical and physical data
FormulaC19H17NOS
Molar mass307.41 g/mol g·mol-1
3D model (JSmol)
Melting point110 to 111.5 °C (230.0 to 232.7 °F)
 ?N?Y (what is this?)  (verify)

Tolnaftate (INN)[1] is a synthetic thiocarbamate used as an anti-fungal agent that may be sold without medical prescription in most jurisdictions. It is supplied as a cream, powder, spray, and liquid aerosol. Tolnaftate is used to treat fungal conditions such as jock itch, athlete's foot and ringworm.

Mechanism

Although the exact mechanism of action is not entirely known, it is believed to inhibit squalene epoxidase,[2] an important enzyme in the biosynthetic pathway of ergosterol (a key component of the fungal cell membrane) in a similar way to terbinafine.[3]

Uses

Tolnaftate has been found to be generally slightly less effective than azoles when used to treat tinea pedis (athlete's foot). It is, however, useful when dealing with ringworm, especially when passed from pets to humans.[4]

References

  1. ^ a b "International Non-Proprietary Names for Pharmaceutical Preparations. Recommended International Non-Proprietary names (Rec. I.N.N.): List 6" (PDF). World Health Organization. Retrieved 2016.
  2. ^ Ryder NS, Frank I, Dupont MC (May 1986). "Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate". Antimicrob. Agents Chemother. 29 (5): 858-60. doi:10.1128/aac.29.5.858. PMC 284167. PMID 3524433.
  3. ^ "antifung". Archived from the original on 2008-06-17. Retrieved .
  4. ^ Crawford F, Hart R, Bell-Syer S, Torgerson D, Young P, Russell I. Topical treatments for fungal infections of the skin and nails of the foot (Cochrane Review). In: The Cochrane Library, Issue 1, 2003. Oxford: Update Software.

External links


  This article uses material from the Wikipedia page available here. It is released under the Creative Commons Attribution-Share-Alike License 3.0.

Tinactin
 



 



 
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