|Length||516 mi (830 km)|
|South end||at Gulfport, MS|
|North end||/ at Yazoo City, MS|
|South end||/ at Tutwiler, MS|
|North end||/ / at Piggott, AR|
U.S. Route 49 (US 49) is a north–south United States highway. The highway's northern terminus is in Piggott, Arkansas, at an intersection with US Route 62/Highway 1/Highway 139 (US 62/AR 1/AR 139). Its southern terminus is in Gulfport, Mississippi, at an intersection with U.S. Route 90. US 49 is approximately 516 miles (830 km) in length.
It was at the junction of US 49 and U.S. Route 61 that blues singer Robert Johnson is said to have sold his soul to the Devil. The highway is also the subject of songs by Big Joe Williams and Howlin' Wolf (Chester Arthur Burnett).
US 49 has historically been one of the most important highways in Mississippi. It was the state's first highway to see a significant rural segment four-laned. Today, it is the only four-laned route directly connecting Jackson, the state's capital and largest city, to the Mississippi Gulf Coast. Some urban segments along this portion of the route maintain three or more traffic lanes in each direction. US 49 serves as a primary hurricane evacuation route for Gulf Coast residents.
US 49 begins near the Port of Gulfport, Mississippi at a junction with US 90. It provides a major connection between the port, casinos, beaches and downtown with I-10 (exits 34A-B), where it has its first major junction being a full service cloverleaf interchange on the city's north end. The crossing of these two roads is officially recognized by the state of Mississippi as the Castilgia Interchange. North of I-10, US 49 passes through suburban areas and enters De Soto National Forest. Various state highway interchanges and junctions are encountered before the route passes near Camp Shelby, then through an interchange with US 98 just south of Hattiesburg. At this point, travelers have an option of continuing on US 49 through Hattiesburg or using the I-59/US 98 bypass which reconnects with US 49 in the northern part of the city. Continuing on US 49 brings one to a cloverleaf interchange at US 11, one of very few in the South to lack merging lanes between loop ramps, thus altering the usual weaving patterns which plague many of these interchanges.
US 49 passes Hattiesburg's primary medical facility, Forrest General Hospital, and the campus of the University of Southern Mississippi before arriving at another, more standard cloverleaf interchange with I-59. Those who used the aforementioned bypass, wishing to reconnect with US 49 North to the state capital, must use exit 67B. It is also at I-59, where Mississippi Highway 42 (MS 42) runs with US 49 for a short distance as suburban development is soon encountered as the road returns to rural environs. Eventually, MS 42 departs from the four-laned highway and branches off to the west toward smaller towns, starting with Sumrall. Interchanges between Hattiesburg and Jackson provide access to various state highways, and one at Collins provides access to US 84.
At Jackson, US 49 upgrades to Interstate Highway standards before joining I-20 using a two-lane flyover. About a mile later, I-20/US 49 merges with I-55 at a stack interchange. I-20/I-55/US 49 crosses the Pearl River into Hinds County and bypasses Downtown Jackson, where I-55 departs to the south. US 49/I-20 continue west until US 49 ends its run with I-20 and joins I-220 before turning northwest to Yazoo City. A split in the highway, rare in the U.S. Highway System, begins here; both routes head into the Mississippi Delta, US 49W serving the towns of Belzoni and Indianola, where it junctions with US 82 and its four-lane segment ends, while two-laned US 49E serves Tchula before encountering US 82 at Greenwood. Both routes continue north from US 82 and are linked again at Tutwiler. Continuing northwest, the highway passes through an interchange with US 61 as it enters Clarksdale. It is at Clarksdale that US 49 encounters "The Crossroads", the legendary junction with State Street (an old alignment of US 61) where the great blues musician Robert Johnson is reputed to have sold his soul to the devil.
In May 2005 portions of extant US 49E were renamed the "Emmett Till Memorial Highway".
The Mississippi section of US 49 and the routes of US 49E and US 49W are defined at Mississippi Code Annotated § 65-3-3.
US 49 enters Arkansas near Helena-West Helena in Phillips County. US 49 Business runs around the north part of the city, with the main route meeting AR 242 in the southern portion. US 49 continues west to Walnut Corner where the route meets AR 1 (and briefly AR 316). The US 49/AR 1 concurrency ends in Marvell, and US 49 enters Monroe County.
Upon entering Monroe County, US 49 turns north to begin a concurrency with AR 39. US 49 also crosses US 79 before meeting US 70 near Brinkley. The route crosses Interstate 40 north of Brinkley prior to entering Woodruff County. US 49 runs northeast through rural Woodruff County, not crossing of concurring with any important routes before crossing into Cross County.
The route meets US 64 in Fair Oaks, and meets AR 42 in southern Hickory Ridge. It then enters Poinsett County, concurring with AR 214 from Fisher until Waldenburg. The route crosses AR 14 in Waldenburg.
US 49 runs along south Jonesboro, with US 49 Business formerly running into town. US 49 concurs with US 63 until again joining AR 1. The two routes angle north through downtown Jonesboro, crossing US 63 Business and passing by ASU Stadium before leaving town. US 49/AR 1 pass around Brookland, with US 49 Business serving the community.
Entering Greene County, US 49/AR 1 briefly meets AR 358 before entering Paragould. The routes cross US 412 near Kirk Field in Paragould, also meeting AR 135 north of town. US 49 Business also rejoins US 49/AR 1 north of Paragould.
Continuing northeast through rural Greene County, US 49/AR 1 meet AR 34 in Marmaduke and AR 90 in Rector. The route turns north to Piggott at Hargrave Corner, terminating at US 62/AR 139. The Arkansas portion of US 49 is mainly two-lane undivided.
One of the original US highways, US 49 was extended north from Clarksdale, Mississippi to US 70 in Brinkley, Arkansas via U.S. Route 61 and Highway 6 in 1963. US 49 was again extended north in 1978, replacing Highway 39 between Brinkley and Jonesboro.Highway 1 between Jonesboro and Piggott was redesignated as US 49 in 1979.
It is notable that for several years during the 1930s, a second split route existed on US 49 in South Mississippi, similar to but shorter than the split that still exists in the Delta region. Between Brooklyn and Hattiesburg, travelers had the option of a 24-mile-long (39 km) direct route via US 49W, or a somewhat shorter but broken route on US 49E, serving the Forrest County Agricultural High School and the small community of McLaurin, Mississippi.
This section contains a table that is missing mileposts for one or more junctions.
|Mississippi||Harrison||Gulfport||0.00||0.00||- Biloxi, Long Beach, Ship Island Ferry||Southern terminus; road continues as 25th Street|
|- New Orleans, Biloxi, Mobile||I-10 exit 34|
|north - Poplarville, Lyman Fish Hatchery|
|||south - D'Iberville, Biloxi||Interchange|
|Stone||Wiggins||north to - Downtown Wiggins, South Wiggins, Flint Creek Water Park|
|- Poplarville, Lucedale||Interchange|
|south to - Downtown Wiggins, Flint Creek Water Park|
|Forrest||||north - Lumberton|
|Hattiesburg||to - Columbia, Laurel, Lucedale, Mobile||Interchange|
|Edwards Street (MS 969)|
|(Broadway Drive) - Purvis||Interchange|
|west (Hardy Street) to / - Columbia|
|Old Highway 42 - Petal||Former MS 42 east|
|/ east - New Orleans, Gulf Coast, Laurel, Airport||I-59 exit 67; south end of MS 42 overlap|
|||west - Sumrall, Prentiss||North end of MS 42 overlap|
|Covington||||east - Sanford|
|Seminary||south - Sumrall|
|east - Seminary|
|Collins||- Downtown Collins||Interchange|
|- Prentiss, Laurel||Interchange|
|Mount Olive||- Bassfield, Columbia, Mount Olive, Mize|
|south - Mount Olive|
|east - Mize, Laurel||South end of MS 28 overlap|
|north - Downtown Magee||South end of MS 28 overlap|
|west / south - Georgetown, Hazlehurst||North end of MS 28 / MS 541 overlap|
|to - Boswell Regional Center (Department of Mental Health)||Interchange via connector roads|
|||south - Sanatorium||South end of MS 149 overlap|
|Mendenhall||north||North end of MS 149 overlap|
|- Mendenhall, Prentiss, Puckett||Interchange|
|Rankin||Florence||- Downtown Florence, Brandon|
|Richland||Old Highway 49||Proposed MS 149 north; northbound exit and southbound entrance|
|East Frontage Road||Interchange; northbound exit and entrance|
|West Frontage Road||Interchange; southbound exit and entrance|
|Richland-Pearl line||east to - Flowood, Meridian||South end of I-20 overlap; I-20 exit 47A|
|Jackson||west / begin - Vicksburg||North end of I-20 overlap; south end of I-220 overlap; I-20 exit 41|
|north||North end of I-220 overlap; I-220 exit 5B|
|Natchez Trace Parkway||Interchange|
|Madison||Flora||- Edwards, Flora, Canton, Mississippi Petrified Forest National Natural Landmark|
|Yazoo||Bentonia||Bentonia||Proposed MS 830|
|- Satartia, Bentonia|
|east - Bentonia|
|||east - Benton, Canton||South end of MS 16 overlap|
|Yazoo City||west / north - Downtown Yazoo City||North end of MS 16 overlap|
|north (Jerry Clower Boulevard) / north (Haley Barbour Parkway) to south - Greenwood, Indianola, Vicksburg||Interchange; US 49 north splits into US 49E and US 49W|
|See US 49E and US 49W|
|Tallahatchie||Tutwiler||south ( south) / south - Indianola, Greenwood||South end of MS 3 overlap; US 49 south splits into US 49E and US 49W|
|north - Marks, Lambert||North end of MS 3 overlap|
|Coahoma||Clarksdale||east||South end of MS 322 overlap|
|south / west / west - Clarksdale, Cleveland, Greenville, Delta Blues Museum||Interchange; north end of MS 322 overlap; south end of US 61 / US 278 overlap|
|east / - Clarksdale, Batesville||North end of US 278 overlap|
|||south - Lyon, North Clarksdale|
|||Friars Point-Highway 61 / Highway 61-Jonestown - Friars Point, Moon Lake||Proposed MS 316|
|||north / south (Lula-Rich) - Tunica, Memphis, Sledge, Sardis||North end of US 61 overlap|
|||south - Friars Point, North Delta Museum|
|Arkansas||Phillips||Helena-West Helena||0.99||1.59||north / north / (Biscoe Drive) - Business District||South end of Great River Road overlap|
|1.35||2.17||/ south to - Lakeview, Elaine, Harbor and Industrial Park||North end of Great River Road overlap|
|6.28||10.11||south (North Sebastian Street) - Business District|
|6.88||11.07||north - Municipal Airport|
|Walnut Corner||12.48||20.08||north / south - Barton, Lake View|
|Kindall||15.45||24.86||north - Rondo|
|Poplar Grove||17.58||28.29||south - Trenton|
|21.52||34.63||south - DeWitt|
|||27.56||44.35||south - Postelle, Turner|
|||29.67||47.75||west - Holly Grove|
|Monroe||||33.56||54.01||east - Louisiana Purchase Historic State Park|
|||35.60||57.29||north - Blackton|
|||38.67||62.23||- Clarendon, Marianna, Stuttgart, Holly Grove|
|||43.55||70.09||south / to - Rich|
|Brinkley||51.80||83.36||west - DeValls Bluff||South end of US 70 overlap|
|52.55||84.57||east (West Sycamore Street)|
|53.39||85.92||east (West Cypress Street)||North end of US 70 overlap|
|54.97||88.47||(US 63) - Little Rock, Memphis||I-40 exit 216|
|56.13||90.33||north - Cotton Plant|
|Woodruff||||62.47||100.54||west - Cotton Plant|
|Cross||Fair Oaks||80.26||129.17||west - Bald Knob||South end of US 64 overlap|
|80.28||129.20||east - Wynne||North end of US 64 overlap|
|Tilton||84.88||136.60||east - Vanndale|
|Hickory Ridge||90.44||145.55||to - Cherry Valley|
|Poinsett||Fisher||96.67||155.58||east - White Hall|
|Waldenburg||102.74||165.34||- Newport, Harrisburg|
|||104.9||168.8||- Lake Hogue Public Fishing|
|||109.34||175.97||west - Grubbs|
|Craighead||Jonesboro||120.50||193.93||west to /|
|125.53||202.02||north / east (Southwest Drive) - Walnut Ridge, Hoxie||South end of US 63 overlap; US 49 south follows exit 45|
|126.75||203.98||(Harrisburg Road)||US 63 exit 44|
|128.40||206.64||south / south (Stadium Boulevard) / Caraway Road - Memphis, Harrisburg||North end of US 63 overlap; south end of AR 1 overlap; US 49 north follows exit 42|
|129.53||208.46||south / (East Highland Drive) - Blytheville|
|131.74||212.01||north (East Johnson Avenue) to - Jonesboro Business District||AR 91 southern terminus|
|132.31||212.93||north / (Old Greensboro Road)||South end of AR 351 overlap|
|132.75||213.64||(Airport Road) - Airport||North end of AR 351 overlap|
|||136.7||220.0||north - Brookland Business District|
|||140.60||226.27||south - Brookland Business District|
|149.71||240.93||/ north - Walnut Ridge, Cardwell MO, Paragould Business District, Airport|
|149.97||241.35||to west - Walnut Ridge|
|151.13||243.22||/ - Corning, Business District|
|Marmaduke||161.44||259.81||- Business District|
|Clay||Rector||168.86||271.75||west - Rector Business District||South end of AR 90 overlap|
|Hargrave Corner||172.33||277.34||east - Kennett MO||North end of AR 90 overlap|
|Piggott||182.33||293.43||/ north / - Corning, St. Francis, Piggott Business District||Northern terminus; north end of AR 1 overlap; road continues as Thornton Avenue|
|1.000 mi = 1.609 km; 1.000 km = 0.621 mi|