D'Hose was appointed to the Belgian Federal Parliament for Open VLD in July 2019, and delegated to the Senate. In the division of powers within the Alexander De Croo government, Open VLD was given the Senate presidency in October 2020, and D'Hose was nominated for the role. At, 39 she became the youngest person to hold the position. Later that month she became seriously ill with a blood infection and was confined to bed. She tested negative for Covid-19.