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Halep was the reigning champion from when the tournament was last held in 2019, but she withdrew from this year's competition due to a calf injury. Williams retired from her first-round match against Aliaksandra Sasnovich due to injury. This marked only the second time that she had lost in the first round of a major, following her defeat at the 2012 French Open to Virginie Razzano. It marked the first time since 2014 that the Wimbledon final did not feature one of the Williams sisters when Venus Williams was ousted by Ons Jabeur in the second round, as well as the first time since 1997 that neither sister progressed beyond the second round.
This was the first edition of Wimbledon since 2009 that saw the top two seeds progress to the semifinals.Garbiñe Muguruza's loss in the third round guaranteed two first-time Wimbledon semifinalists, Plí?ková and Sabalenka, from the bottom half of the draw. Additionally, this was the first Grand Slam tournament in the Open Era where two wildcards, Liudmila Samsonova and Emma Raducanu, reached the fourth round. Furthermore, Raducanu became the youngest British woman to reach the fourth round at Wimbledon in the Open Era. This was Raducanu's first appearance in the main draw of a major; she would claim her first major title on her next attempt at the US Open. Jabeur became the first Tunisian player and the first Arabian woman in history to reach the quarterfinals at Wimbledon.