|2022 Open de Oeiras II|
|Nuno Borges / Francisco Cabral|
The 2022 Open de Oeiras II was a professional tennis tournament played on clay courts. It was the sixth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Oeiras, Portugal between 4 and 10 April 2022.
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw: