Moiety (chemistry)
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Moiety Chemistry
Benzyl acetate contains a benzyloxy moiety (encircled with light orange). It also contains an ester functional group (in red), and an acetyl functional group (encircled with dark green). Other divisions can be made.

In organic chemistry, a moiety is a part of a molecule[1][2] that is given a name because it is identified as a part in other molecules as well.

Typically, the term is reserved to describe the larger and characteristic parts of organic molecules; and it should not be used to describe/name smaller functional groups [1][2] of atoms, which chemically react in similar ways in most molecules containing them.[3] Occasionally, moieties may be composed of yet smaller moieties and functional groups.

Moieties as branches that extend from the backbone of a hydrocarbon molecule are called substituents or side chains; typically, they can be broken off and substituted with others.

Active moiety

In pharmacology, an active moiety is the part of a molecule or ion - excluding appended inactive portions - that is responsible for the physiological or pharmacological action of a drug substance. Inactive appended portions of the drug substance may include either the alcohol or acid moiety of an ester, a salt (including a salt with hydrogen or coordination bonds), or other noncovalent derivative (such as a complex, chelate, or clathrate).[4][5] The parent drug may itself be an inactive prodrug and only after the active moiety is released from the parent in free form does it become active.

See also

References

  1. ^ a b IUPAC, Compendium of Chemical Terminology, 2nd ed. (the "Gold Book") (1997). Online corrected version:  (2006–) "moiety". doi:10.1351/goldbook.M03968
  2. ^ a b "Illustrated Glossary of Organic Chemistry - Moiety". web.chem.ucla.edu. Retrieved .
  3. ^ IUPAC, Compendium of Chemical Terminology, 2nd ed. (the "Gold Book") (1997). Online corrected version:  (2006–) "functional group". doi:10.1351/goldbook.F02555
  4. ^ "CFR - Code of Federal Regulations Title 21". United States Food and Drug Administration. 1 April 2018. Retrieved 2019.
  5. ^ "Electronic Code of Federal Regulations Title 21: Food and Drugs § 314.3". Electronic Code of Federal Regulations. United States Government Publishing Office. 22 January 2019. Retrieved 2019. Active moiety is the molecule or ion, excluding those appended portions of the molecule that cause the drug to be an ester, salt (including a salt with hydrogen or coordination bonds), or other noncovalent derivative (such as a complex, chelate, or clathrate) of the molecule, responsible for the physiological or pharmacological action of the drug substance.

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Moiety_(chemistry)
 



 



 
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